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Analysis of serial electroencephalographic predictors of seizure recurrence in Rolandic epilepsy

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Abstract

Purpose

We aimed to assess the relationship between electroencephalography (EEG) markers and seizure recurrence in cases with benign epilepsy with centrotemporal spikes (BECT) in a long-term follow-up study.

Methods

We analyzed the data of 52 children with BECT who were divided into 2 groups: the isolated group and recurrence group. The clinical profiles and initial/serial visual EEG recordings of both groups were evaluated. The entire follow-up period ranged from 12 to 65 months.

Results

None of the clinical characteristics differed between the 2 groups. Serial EEGs showed that the appearance of Rolandic spikes in the frontal region was more prevalent in the recurrence group. Moreover, a significant correlation was found between bilateral asynchronous discharges and seizure recurrence. However, on initial EEG of these patients, neither of the EEG features exhibited statistical significance.

Conclusion

The presence of frontal focus and bilateral asynchrony appeared to be hallmarks of BECT patients with higher risk for seizure recurrence.

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Abbreviations

EEG:

electroencephalography

BECT:

Benign epilepsy with centrotemporal spikes

MRI:

Magnetic resonance imaging

AEDs:

Antiepileptic drugs

LEV:

Levetiracetam

OXC:

Oxcarbazepine

VPA:

Valproate

CZP:

Clonazepam

OR:

Odds ratio

CI:

Confidence interval

NS:

Not significant

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Funding

This work was supported by Wuxi Young Medical Talents (Grant Number QNRC021); Medical Innovation Team of Jiangsu Province (Grant Number CXTDB2017016); and Wuxi Medical Development Discipline (Grant Number FZXK001).

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Author notes

  1. Hongwei Tang and Yan** Wang contributed equally to this work.

Authors and Affiliations

  1. Department of Neurology, Wuxi Children’s Hospital, 299 Qingyang Road, Wuxi, 214023, Jiangsu Province, China

    Hongwei Tang, Yan** Wang, Ying Hua, Jianbiao Wang, Miao **g & **aoyue Hu

Authors
  1. Hongwei Tang
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  2. Yan** Wang
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  3. Ying Hua
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  4. Jianbiao Wang
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  5. Miao **g
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  6. **aoyue Hu
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Correspondence to **aoyue Hu.

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Tang, H., Wang, Y., Hua, Y. et al. Analysis of serial electroencephalographic predictors of seizure recurrence in Rolandic epilepsy. Childs Nerv Syst 35, 1579–1583 (2019). https://doi.org/10.1007/s00381-019-04275-0

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  • DOI: https://doi.org/10.1007/s00381-019-04275-0

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