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C-grooved dual-core PCF SPR biosensor with graphene/au coating for enhanced early cancer cell detection

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Abstract

We propose a dual-core, highly sensitive PCF SPR biosensor with C-shaped grooves based on a fusion of graphene and gold film. The performance of our sensor is enhanced by our circular fibre lattice with perforated air holes. We evaluate the biosensor's sensitivity to variations in refractive index (RI) in cancer cells numerically using the Finite Element Method (FEM) in COMSOL Multiphysics. After enhancing fiber parameters and using numerical results from amplitude method and spectral interrogation methods, we found that the biosensor demonstrates the highest sensitivity for MCF7 cells, 2142.86 nm/RIU under spectral interrogation. With HeLa cells, the biosensor shows a sensitivity of – 1058.039 1/RIU under the amplitude interrogation approach. Moreover, for MCF7, the biosensor reaches a resolution of 04.60 × 1E–5 RIU.

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Acknowledgements

The authors extend their sincere gratitude to the National Institute of Technology Nagaland (NIT Nagaland), Chumukedima-797103, for their invaluable support and assistance. The expertise and guidance provided by the staff were instrumental in enabling the authors to effectively utilize the software COMSOL Multiphysics, a powerful commercial simulation tool that facilitated the research with precision and accuracy.

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Authors and Affiliations

  1. Department of Electronics and Instrumentation Engineering, National Institute of Technology, Dimapur, Nagaland, 797103, India

    Khalid Mohd Ibrahimi, R. Kumar & Writtick Pakhira

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  1. Khalid Mohd Ibrahimi
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  2. R. Kumar
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  3. Writtick Pakhira
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Contributions

Khalid Mohd Ibrahimi played a vital part in constructing the design and concept for the research, conducting detailed analysis and investigation of the suggested design, Verifying the simulation programme, and drafting the initial manuscript. R. Kumar contributed significantly to the supervision of the research, conducting thorough investigations, reviewing the manuscript, and editing the final version.

Writtick Pakhira significantly contributed to the preparation of tables and figures.

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Correspondence to Khalid Mohd Ibrahimi.

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Ibrahimi, K.M., Kumar, R. & Pakhira, W. C-grooved dual-core PCF SPR biosensor with graphene/au coating for enhanced early cancer cell detection. Appl. Phys. A 130, 439 (2024). https://doi.org/10.1007/s00339-024-07593-6

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