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Intermediate analysis of magnesium alloy covered stent for a lateral aneurysm model in the rabbit common carotid artery

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Abstract

Objective

To analyze the outcomes of a magnesium alloy covered stent (MACS) for a lateral aneurysm model in common carotid artery (CCA).

Methods

In 32 rabbits, a MACS (group A, n = 17) or a Willis covered stent (WCS; group B, n = 15) was inserted and the rabbits were sacrificed 1, 3, 6, or 12 months after stenting. Angiography and intravascular ultrasound (IVUS) were performed at 3, 6, and 12 months. Scanning electron microscopy was performed for six stents in each group at 1, 3, and 6 months, and histopathology and histomorphology were conducted at 3 (n = 4), 6 (n = 4), and 12 (n = 12) months.

Results

Final angiography showed complete occlusion of the aneurysms in 12 cases. IVUS at 6 and 12 months revealed a significant increase in mean lumen area of the stented CCA in group A and also showed greater mean lumen area in group A than in group B. The endothelialization process was quicker in group A than in group B.

Conclusion

MACS is effective for occlusion of lateral aneurysms and is superior to WCS in growth of the stented CCA and endothelialization. Further work is needed to make this device available for human use.

Key points

• The MACS is an effective approach for occlusion of a lateral aneurysm.

• IVUS showed that the CCA could grow following degradation of the MACS.

• The lumen area of the stented CCA was excellent in MACS.

• HE staining displayed the degradation of the magnesium alloy stent.

• Combination of IVUS and DSA were applied in this study.

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Abbreviations

MACS:

Magnesium alloy covered stent

WCS:

Willis covered stent

CCA:

Common carotid artery

3D-TOF-MRA:

Three dimensional time-of-flight of magnetic resonance angiography

CA:

Cerebral aneurysm

DSA:

Digital subtraction angiography

IVUS:

Intravascular ultrasound

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Acknowledgements

The scientific guarantor of this publication is Yong-Dong Li.

The authors of this manuscript declare no relationships with any companies, whose products or services may be related to the subject matter of the article.

This work was supported the National Health and Family Planning Commission [grant number 201301006], the Interdisciplinary Program of Shanghai Jiao Tong University [grant number YG2015MS11], the Special Project of Chinese National Key R & D Program [grant number 2016YFC1102400], the National Natural Science Foundation of China [grant number 51571143], the Foundation of Shanghai Committee of Science and Technology Development of China [grant number 1241191201], and the Foundation of Shanghai Municipal Commission of Health and Family Planning [grant number 20124175].

No complex statistical methods were necessary for this paper.

Institutional Review Board approval was obtained.

Written informed consent was obtained from all subjects (patients) in this study.

No study subjects or cohorts have been previously reported.

Methodology:

• retrospective

• diagnostic or prognostic study

• performed at one institution

Author information

Authors and Affiliations

  1. Department of Interventional Radiology, The First Affiliated Hospital, **nxiang Medical University, **nxiang, Henan Province, China

    Hong-kai Cui, Fen-Bao Li, Ying-Chang Guo, Yong-Li Zhao, Rui-Fang Yan & Yong-Dong Li

  2. No.88, Jian Kang Road, Weihui, 453100, Henan Province, China

    Hong-kai Cui, Fen-Bao Li, Ying-Chang Guo, Yong-Li Zhao, Rui-Fang Yan & Yong-Dong Li

  3. Department of Interventional Radiology, Shanghai Jiao Tong University Affiliated Sixth People’s Hospital, (Fengxian Hospital), Shanghai, 200233, China

    Wu Wang, Yong-Dong Li & Yong-Li Wang

  4. No. 600, Yi Shan Road, Shanghai, 200233, China

    Wu Wang & Yong-Dong Li

  5. No. 6600, Nan Feng Road, Shanghai, 210499, China

    Yong-Li Wang

  6. National Engineering Research Center of Light Alloy Net Forming and State Key Laboratory of Metal Matrix Composite, Shanghai Jiao Tong University, Shanghai, 200240, China

    Guang-Yin Yuan

  7. No. 800, Dong Chuan Road, Shanghai, 200240, China

    Guang-Yin Yuan

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  1. Hong-kai Cui
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  7. Yong-Dong Li
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Corresponding authors

Correspondence to Yong-Dong Li, Yong-Li Wang or Guang-Yin Yuan.

Additional information

Fen-Bao Li is Co-first author

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Cui, Hk., Li, FB., Guo, YC. et al. Intermediate analysis of magnesium alloy covered stent for a lateral aneurysm model in the rabbit common carotid artery. Eur Radiol 27, 3694–3702 (2017). https://doi.org/10.1007/s00330-016-4715-6

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  • DOI: https://doi.org/10.1007/s00330-016-4715-6

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