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Core items to be included in a definition of moderate psoriatic arthritis: literature review and expert opinion

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Abstract

Evidence-based treatment recommendations for psoriatic arthritis (PsA) suggest that treatment should be individualised but acknowledge the difficulty of correctly defining levels of activity (mild, moderate and severe). The aim of this study was to define the parameters or disease characteristics that should be included in a future definition of moderate PsA. Mixed. methods: (1) literature review to identify previous assessment tools used to classify patients into mild, moderate and severe forms, and (2) survey of rheumatologists, and experts in PsA, to obtain their opinion on the degree of validation and applicability of published definitions and tools, and on the parameters that should be included in a future definition of moderate PsA. We propose eight domains/items to be included in a definition of moderate PsA: number of active joints and inflamed entheses, physician global assessment (by visual analogue scale), dactylitis, body surface area (BSA) affected by psoriasis, psoriasis in special locations, and absence of hip involvement. The Disease Activity Index for Psoriatic Arthritis (DAPSA) score would be supported as part of this definition, as would the Psoriatic Arthritis Impact of Disease (PsAID) index. This study proposes a set of items/domains to be included in a definition of moderate PsA based on literature and expert opinion, which can be the starting point for further development and validation studies of the proposed items.

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References

  1. Coates LC, Helliwell PS (2017) Psoriatic arthritis: state of the art review. Clin Med (Lond) 17(1):65–70. https://doi.org/10.7861/clinmedicine.17-1-65

    Article  PubMed  Google Scholar 

  2. Van den Bosch F, Coates L (2018) Clinical management of psoriatic arthritis. Lancet 391(10136):2285–2294. https://doi.org/10.1016/S0140-6736(18)30949-8

    Article  PubMed  Google Scholar 

  3. Romero Perez A, Queiro R, Seoane-Mato D, Graell E, Chamizo E, Chaves Chaparro L et al (2020) Higher prevalence of psoriatic arthritis in the adult population in Spain? A population-based cross-sectional study. PLoS ONE 15(6):e0234556. https://doi.org/10.1371/journal.pone.0234556

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  4. Ritchlin CT, Colbert RA, Gladman DD, Psoriatic Arthritis (2017) N Engl J Med 376(10):957–70. https://doi.org/10.1056/NEJMra1505557.

    Article  PubMed  Google Scholar 

  5. Moll JM, Wright V (1973) Psoriatic arthritis. Semin Arthritis Rheum 3(1):55–78. https://doi.org/10.1016/0049-0172(73)90035-8

    Article  CAS  PubMed  Google Scholar 

  6. Coates LC, Corp N, van der Windt DA, Soriano ER, Kavanaugh A (2021) GRAPPA Treatment Recommendations: An Update From the 2020 GRAPPA Annual Meeting. J Rheumatol Suppl. 97:65 – 6. https://doi.org/10.3899/jrheum.201681

  7. Gialouri CG, Fragoulis GE (2021) Disease activity indices in psoriatic arthritis: current and evolving concepts. Clin Rheumatol 40(11):4427–4435. https://doi.org/10.1007/s10067-021-05774-9

    Article  PubMed  Google Scholar 

  8. Llamas-Velasco M, de la Cueva P, Notario J, Martinez-Pilar L, Martorell A, Moreno-Ramirez D (2017) Moderate psoriasis: a proposed definition. Actas Dermosifiliogr 108(10):911–917. https://doi.org/10.1016/j.ad.2017.07.002

    Article  CAS  PubMed  Google Scholar 

  9. Torre Alonso JC, Diaz Del Campo Fontecha P, Almodovar R, Canete JD, Montilla Morales C, Moreno M et al (2018) Recommendations of the Spanish Society of Rheumatology on treatment and use of systemic biological and non-biological therapies in psoriatic arthritis. Reumatol Clin (Engl Ed) 14(5):254–268. https://doi.org/10.1016/j.reuma.2017.08.007

    Article  PubMed  Google Scholar 

  10. Gossec L, Baraliakos X, Kerschbaumer A, de Wit M, McInnes I, Dougados M et al (2020) EULAR recommendations for the management of psoriatic arthritis with pharmacological therapies: 2019 update. Ann Rheum Dis 79(6):700–712. https://doi.org/10.1136/annrheumdis-2020-217159

    Article  PubMed  Google Scholar 

  11. Gossec L, Kerschbaumer A, Ferreira RJO, Aletaha D, Baraliakos X, Bertheussen H et al (2024) EULAR recommendations for the management of psoriatic arthritis with pharmacological therapies: 2023 update. Ann Rheum Dis. https://doi.org/10.1136/ard-2024-225531

    Article  PubMed  Google Scholar 

  12. Haddaway NRAUPCC, McGuinness LA (2021) PRISMA2020: R package and ShinyApp for producing PRISMA 2020 compliant flow diagrams (Version 0.0.2). Zenodo

  13. Armstrong AW, Robertson AD, Wu J, Schupp C, Lebwohl MG (2013) Undertreatment, treatment trends, and treatment dissatisfaction among patients with psoriasis and psoriatic arthritis in the United States: findings from the National Psoriasis Foundation surveys. JAMA Dermatol 149(10):2003–2011. https://pubmed.ncbi.nlm.nih.gov/23945732/. https://jamanetwork.com/journals/jamadermatology/articlepdf/1729130/doi130034.pdf

    Article  Google Scholar 

  14. Elmets CA, Leonardi CL, Davis DMR, Gelfand JM, Lichten J, Mehta NN et al (2019) Joint AAD-NPF guidelines of care for the management and treatment of psoriasis with awareness and attention to comorbidities. J Am Acad Dermatol 80(4):1073–1113. https://doi.org/10.1016/j.jaad.2018.11.058

    Article  PubMed  Google Scholar 

  15. Horn EJ, Fox KM, Patel V, Chiou CF, Dann F, Lebwohl M (2007) Are patients with psoriasis undertreated? Results of National Psoriasis Foundation survey. J Am Acad Dermatol 57(6):957 – 62. https://doi.org/10.1016/j.jaad.2007.06.042.

    Article  PubMed  Google Scholar 

  16. Knuckles MLF, Levi E, Soung J (2018) Defining and treating moderate plaque psoriasis: a dermatologist survey. J Dermatolog Treat 29(7):658 – 63. https://doi.org/10.1080/09546634.2018.1443200.

    Article  PubMed  Google Scholar 

  17. Kulkarni AS, Horn E, Balkrishnan R, Feldman S (eds) Severity levels in psoriasis: a separate ‘very severe’ category not required. J Dermatol Treat. 1 ed. England 2009. pp. 48–51

  18. American Academy of Dermatology, Work G, Menter A, Korman NJ, Elmets CA, Feldman SR, Gelfand JM et al (2011) Guidelines of care for the management of psoriasis and psoriatic arthritis: Sect. 6. Guidelines of care for the treatment of psoriasis and psoriatic arthritis: case-based presentations and evidence-based conclusions. J Am Acad Dermatol 65(1):137–174. https://doi.org/10.1016/j.jaad.2010.11.055

    Article  Google Scholar 

  19. Merola JF, Shrom D, Eaton J, Dworkin C, Krebsbach C, Shah-Manek B et al (2019) Patient perspective on the Burden of skin and joint symptoms of psoriatic arthritis: results of a multi-national patient survey. Rheumatol Ther 6(1):33–45. https://doi.org/10.1007/s40744-018-0135-1

    Article  PubMed  PubMed Central  Google Scholar 

  20. Mijušković ZP, Kandolf-Sekulović L, Tiodorović D, Nikolić M, Jovanović M, Škiljević D et al (2016) Serbian association of dermatovenereologists’ guidelines for the diagnosis and treatment of psoriasis. Serb J Dermatol Venerol 8(2):61–78. https://www.embase.com/search/results?subaction=viewrecord&id=L616473783&from=export U2 - L616473783

    Article  Google Scholar 

  21. Ogdie A, Coates LC, Mease P (2020) Measuring outcomes in Psoriatic Arthritis. Arthritis Care Res (Hoboken) 72(Suppl 10):82–109. https://doi.org/10.1002/acr.24242

    Article  PubMed  Google Scholar 

  22. Wilson HD, Mutebi A, Revicki DA, Mease PJ, Genovese MC, Erondu N et al (2015) Reliability and validity of the Psoriasis Symptom Inventory in patients with psoriatic arthritis. Arthritis Care Res (Hoboken) 67(12):1750–1756. https://doi.org/10.1002/acr.22653

    Article  CAS  PubMed  Google Scholar 

  23. Cazzaniga S, Anzengruber F, Augustin M, Boehncke WH, Borradori L, Conrad C et al (2019) Linkage between patients’ characteristics and prescribed systemic treatments for psoriasis: a semantic connectivity map analysis of the Swiss Dermatology Network for targeted therapies registry. J Eur Acad Dermatol Venereol 33(12):2313–2318. https://pubmed.ncbi.nlm.nih.gov/31562785/. https://onlinelibrary.wiley.com/doi/abs/10.1111/jdv.15983

    Article  CAS  PubMed  Google Scholar 

  24. EMEA. Committee for medical products for human use of EMEA Guideline on clinical investigation of medicinal products indicated for the treatment of psoriasis. European Medicines Agency Evaluation of Medicines for Human use, UEMEA/CHMP/EWP/2454/02 2004 [Available from: http://www.euma.europa.eu/

  25. Lubrano E, Cantini F, Costanzo A, Girolomoni G, Prignano F, Olivieri I et al (2015) Measuring psoriatic disease in clinical practice. An expert opinion position paper. Autoimmun Rev 14(10):864 – 74. https://doi.org/10.1016/j.autrev.2015.05.010.

    Article  PubMed  Google Scholar 

  26. Helliwell PS, Deodhar A, Gottlieb AB, Boehncke WH, Xu XL, Xu S et al (2020) Composite measures of Disease Activity in Psoriatic Arthritis: comparative instrument performance based on the efficacy of Guselkumab in an interventional phase II trial. Arthritis Care Res (Hoboken) 72(11):1579–1588. https://doi.org/10.1002/acr.24046

    Article  CAS  PubMed  Google Scholar 

  27. Gezer HH, Duruöz MT, Nas K, Kılıç E, Sargın B, Kasman SA et al (2022) Inconsistencies of the Disease Activity Assessment Tools for Psoriatic Arthritis: challenges to rheumatologists. Joint Bone Spine 89(3):105296. https://doi.org/10.1016/j.jbspin.2021.105296

    Article  PubMed  Google Scholar 

  28. Benucci M, Gobbi FL, Bandinelli F, Damiani A, Infantino M, Grossi V et al (2017) Safety, efficacy and immunogenicity of switching from innovator to biosimilar infliximab in patients with spondyloarthritis: a 6-month real-life observational study. Immunol Res 65(1):419–422. https://doi.org/10.1007/s12026-016-8843-5

    Article  CAS  PubMed  Google Scholar 

  29. Acosta Felquer ML, Ferreyra Garrott L, Marin J, Catay E, Scolnik M, Scaglioni V et al (2014) Remission criteria and activity indices in psoriatic arthritis. Clin Rheumatol 33(9):1323–1330. https://doi.org/10.1007/s10067-014-2626-y

    Article  CAS  PubMed  Google Scholar 

  30. Mumtaz A, FitzGerald O (2010) Application of the GRAPPA psoriatic arthritis treatment recommendations in clinical practice. Curr Rheumatol Rep 12(4):264 – 71. https://doi.org/10.1007/s11926-010-0109-y.

    Article  PubMed  Google Scholar 

  31. Mumtaz A, Gallagher P, Kirby B, Waxman R, Coates LC, Veale JD et al (2011) Development of a preliminary composite disease activity index in psoriatic arthritis. Ann Rheum Dis 70(2):272–277. https://doi.org/10.1136/ard.2010.129379

    Article  PubMed  Google Scholar 

  32. Aletaha D, Alasti F, Smolen JS (2017) Disease activity states of the DAPSA, a psoriatic arthritis specific instrument, are valid against functional status and structural progression. Ann Rheum Dis 76(2):418–21. https://doi.org/10.1136/annrheumdis-2016-209511.

    Article  CAS  PubMed  Google Scholar 

  33. Fei JZ, Perruccio AV, Ye JY, Gladman DD, Chandran V (2020) The relationship between patient acceptable symptom state and disease activity in patients with psoriatic arthritis. Rheumatology (Oxford) 59(1):69–76. https://doi.org/10.1093/rheumatology/kez202

    Article  PubMed  Google Scholar 

  34. Michelsen B, Sexton J, Smolen JS, Aletaha D, Krogh NS, van der Heijde D et al (2018) Can disease activity in patients with psoriatic arthritis be adequately assessed by a modified Disease Activity index for PSoriatic Arthritis (DAPSA) based on 28 joints? Ann Rheum Dis 77(12):1736–1741. https://doi.org/10.1136/annrheumdis-2018-213463

    Article  CAS  PubMed  Google Scholar 

  35. Schoels MM, Aletaha D, Alasti F, Smolen JS (2016) Disease activity in psoriatic arthritis (PsA): defining remission and treatment success using the DAPSA score. Ann Rheum Dis 75(5):811–818. https://doi.org/10.1136/annrheumdis-2015-207507

    Article  PubMed  Google Scholar 

  36. Schoels MM, Landesmann U, Alasti F, Baker D, Smolen JS, Aletaha D (2018) Early response to therapy predicts 6-month and 1-year disease activity outcomes in psoriatic arthritis patients. Rheumatology (Oxford) 57(6):969–976. https://doi.org/10.1093/rheumatology/key004

    Article  PubMed  Google Scholar 

  37. Di Carlo M, Becciolini A, Lato V, Crotti C, Favalli EG, Salaffi F (2017) The 12-item psoriatic arthritis impact of Disease Questionnaire: construct validity, reliability, and interpretability in a clinical setting. J Rheumatol 44(3):279–285. https://doi.org/10.3899/jrheum.160924

    Article  PubMed  Google Scholar 

  38. Mease PJ, Gladman DD, Ogdie A, Coates LC, Behrens F, Kavanaugh A et al (2020) Treatment-to-target with apremilast in psoriatic arthritis: the probability of achieving targets and Comprehensive Control of Disease manifestations. Arthritis Care Res (Hoboken) 72(6):814–21. https://doi.org/10.1002/acr.24134.

    Article  CAS  PubMed  Google Scholar 

  39. van Mens LJJ, van de Sande MGH, Fluri IA, Atiqi S, van Kuijk AWR, Baeten DLP (2017) Residual disease activity and treatment adjustments in psoriatic arthritis in current clinical practice. Arthritis Res Ther 19(1):226. https://doi.org/10.1186/s13075-017-1424-8

    Article  PubMed  PubMed Central  Google Scholar 

  40. Mulder MLM, van Hal TW, van den Hoogen FHJ, de Jong E, Vriezekolk JE, Wenink MH (2020) Measuring disease activity in psoriatic arthritis: PASDAS implementation in a tightly monitored cohort reveals residual disease burden. Rheumatology (Oxford). 00, https://pubmed.ncbi.nlm.nih.gov/33331947/

  41. Naranje P, Prakash M, Sharma A, Dogra S, Khandelwal N (2015) Ultrasound findings in hand joints involvement in patients with psoriatic arthritis and its correlation with clinical DAS28 score. Radiol Res Pract 2015:353657. https://doi.org/10.1155/2015/353657

    Article  PubMed  PubMed Central  Google Scholar 

  42. Sakellariou GT, Sayegh FE, Anastasilakis AD, Kapetanos GA (2013) Leflunomide addition in patients with articular manifestations of psoriatic arthritis resistant to methotrexate. Rheumatol Int 33(11):2917–2920. https://doi.org/10.1007/s00296-012-2534-x

    Article  CAS  PubMed  Google Scholar 

  43. Coates LC, Mumtaz A, Helliwell PS, Mease PJ, Callis-Duffin K, Krueger GG et al (eds) (2011) Development of a disease severity and responder index for psoriatic arthritis (PsA)--report of the OMERACT 10 PsA special interest group. J Rheumatol; Canada

  44. Gladman DD, Landewe R, McHugh NJ, Fitzgerald O, Thaci D, Coates L et al (2010) Composite measures in psoriatic arthritis: GRAPPA 2008. J Rheumatol 37(2):453–61. https://doi.org/10.3899/jrheum.090956.

    Article  PubMed  Google Scholar 

  45. Helliwell PS, Fitzgerald O, Strand CV, Mease PJ (2011) Composite Measures in Psoriatic Arthritis: a report from the GRAPPA 2009 annual meeting. J Rheumatol. 38(3):540–5; https://doi.org/10.3899/jrheum.101116

  46. Ritchlin CT, Kavanaugh A, Gladman DD, Mease PJ, Helliwell P, Boehncke WH et al (eds) (2009) Treatment recommendations for psoriatic arthritis. Ann Rheum Dis

  47. Coates LC, Gladman DD, Nash P, FitzGerald O, Kavanaugh A, Kvien TK et al (2018) Secukinumab provides sustained PASDAS-defined remission in psoriatic arthritis and improves health-related quality of life in patients achieving remission: 2-year results from the phase III FUTURE 2 study. Arthritis Res Ther 20(1):272. https://doi.org/10.1186/s13075-018-1773-y

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  48. Helliwell PS, FitzGerald O, Fransen J (2014) Composite disease activity and responder indices for psoriatic arthritis: a report from the GRAPPA 2013 meeting on development of cutoffs for both disease activity states and response. J Rheumatol 41(6):1212–1217. https://doi.org/10.3899/jrheum.140172

    Article  PubMed  Google Scholar 

  49. Perruccio AV, Got M, Li S, Ye Y, Gladman DD, Chandran V (2020) Treating Psoriatic Arthritis to Target: defining the psoriatic arthritis disease activity score that reflects a state of Minimal Disease Activity. J Rheumatol 47(3):362–368. https://pubmed.ncbi.nlm.nih.gov/31203221/. https://www.jrheum.org/content/jrheum/47/3/362.full.pdf

    Article  PubMed  Google Scholar 

  50. Gladman DD, Starr M, Cividino A, Gaudreau AJ, Jelley J, Nicholson D et al (2021) Canadian rheumatologists’ perspectives on moderate psoriatic arthritis and Oligoarticular Psoriatic Arthritis. J Rheumatol 48(11):1692–1697. https://doi.org/10.3899/jrheum.201195

    Article  PubMed  Google Scholar 

  51. Gottlieb A, Korman NJ, Gordon KB, Feldman SR, Lebwohl M, Koo JY et al (eds) (2008) Guidelines of care for the management of psoriasis and psoriatic arthritis: Sect. 2. Psoriatic arthritis: overview and guidelines of care for treatment with an emphasis on the biologics. J Am Acad Dermatol; United States

  52. Salgado-Boquete L, Carrascosa JM, Llamas-Velasco M, Ruiz-Villaverde R, de la Cueva P, Belinchon I (2021) A New Classification of the Severity of Psoriasis: What’s Moderate Psoriasis? Life (Basel) 11(7). https://doi.org/10.3390/life11070627

  53. Orbai AM, de Wit M, Mease PJ, Callis Duffin K, Elmamoun M, Tillett W et al (2017) Updating the Psoriatic Arthritis (PsA) Core Domain Set: a report from the PsA Workshop at OMERACT 2016. J Rheumatol 44(10):1522–1528. https://doi.org/10.3899/jrheum.160904

    Article  PubMed  PubMed Central  Google Scholar 

  54. Helliwell PS, Coates LC (2015) The definition of remission in psoriatic arthritis: can this be accurate without assessment of multiple domains? Ann Rheum Dis 74(12):e66. https://doi.org/10.1136/annrheumdis-2015-208509

    Article  CAS  PubMed  Google Scholar 

  55. Tillett W, McHugh N, Orbai AM, Ogdie A, Leung YY, Coates LC et al (2020) Outcomes of the 2019 GRAPPA Workshop on continuous composite indices for the Assessment of Psoriatic Arthritis and Membership-recommended next steps. J Rheumatol Suppl 96:11–18. https://doi.org/10.3899/jrheum.200121

    Article  PubMed  Google Scholar 

  56. Benavent D, Plasencia C, Poddubnyy D, Kishimoto M, Proft F, Sawada H et al (2021) Unveiling axial involvement in psoriatic arthritis: an ancillary analysis of the ASAS-perSpA study. Semin Arthritis Rheum 51(4):766–74. https://doi.org/10.1016/j.semarthrit.2021.04.018.

    Article  CAS  PubMed  Google Scholar 

  57. Feld J, Ye JY, Chandran V, Inman RD, Haroon N, Cook R et al (2020) Is axial psoriatic arthritis distinct from ankylosing spondylitis with and without concomitant psoriasis? Rheumatology (Oxford) 59(6):1340–1346. https://doi.org/10.1093/rheumatology/kez457

    Article  PubMed  Google Scholar 

  58. Michelena X, Poddubnyy D, Marzo-Ortega H (2020) Axial psoriatic arthritis: a distinct clinical entity in search of a definition. Rheum Dis Clin North Am 46(2):327–41. https://doi.org/10.1016/j.rdc.2020.01.009.

    Article  PubMed  Google Scholar 

  59. Poddubnyy D, Jadon DR, Van den Bosch F, Mease PJ, Gladman DD (2021) Axial involvement in psoriatic arthritis: an update for rheumatologists. Semin Arthritis Rheum 51(4):880–887. https://doi.org/10.1016/j.semarthrit.2021.06.006

    Article  PubMed  Google Scholar 

  60. Gratacós J, Pablos JL, de Miguel E, Juanola X, Fernández-Carballido C, Ariza R et al (2023) Disease control in patients with psoriatic arthritis in real clinical practice in Spain: MiDAS study. Reumatol Clin (Engl Ed) 19(4):204–210. https://doi.org/10.1016/j.reumae.2022.03.008

    Article  PubMed  Google Scholar 

  61. Cañete JD, Nolla JM, Queiro R, Rodríguez MJ, Ruiz M, Lizán L (2020) Expert Consensus on a set of outcomes to assess the effectiveness of Biologic Treatment in Psoriatic Arthritis: the MERECES Study. J Rheumatol 47(11):1637–1643. https://doi.org/10.3899/jrheum.191056

    Article  PubMed  Google Scholar 

  62. Johnson SR, Naden RP, Fransen J, van den Hoogen F, Pope JE, Baron M et al (2014) Multicriteria decision analysis methods with 1000Minds for develo** systemic sclerosis classification criteria. J Clin Epidemiol 67(6):706–14. https://doi.org/10.1016/j.jclinepi.2013.12.009.

    Article  PubMed  PubMed Central  Google Scholar 

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Amgen provided funding in the past to conduct the literature review and survey by Instituto de Salud Musculoesquelética but did not collaborate in the writing or publishing this manuscript.

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AUA designed the study and selected the panel. LC, MJGdY, JLAV, MLGV, JAPT and RQ critically reviewed the literature and generated input for the survey items. AUA and JAPT circulated the survey to their respective expert groups. All authors contributed to the manuscript.

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Correspondence to Ana Urruticoechea-Arana.

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Urruticoechea-Arana, A., Álvarez-Vega, J.L., García-Vivar, M.L. et al. Core items to be included in a definition of moderate psoriatic arthritis: literature review and expert opinion. Rheumatol Int (2024). https://doi.org/10.1007/s00296-024-05644-y

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