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Hypothermia induced by adenosine 5′-monophosphate attenuates early stage injury in an acute gouty arthritis rat model

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Abstract

To investigate whether the hypothermia induced by Adenosine 5′-Monophosphate (5′-AMP) could attenuate early stage injury in a rat acute gouty arthritis model. Ankle joint injection with monosodium urate monohydrate crystals (MSU crystals) in hypothermia rat model which was induced by 5′-AMP and then observe whether hypothermia induced by 5′-AMP could be effectively inhibit the inflammation on acute gouty arthritis in rats. AMP-induced hypothermia has protective effects on our acute gouty arthritis, which was demonstrated by the following criteria: (1) a significant reduction in the ankle swelling (p < 0.001); (2) a significant decrease in the occurrence of leukocyte infiltration and mild hemorrhage; (3) a significant reduction in the presence of serum Interleukin-1β (IL-1β, p < 0.001) and metalloproteinase-9 (MMP-9, p < 0.001); and (4) a significant inhibition in the Nuclear Factor -κappaB (NF-κB) activity (p < 0.001). AMP-induced hypothermia could inhibit acute inflammation reaction and protect the synovial tissue against acute injury in a rat acute gouty arthritis model.

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Acknowledgments

This work was supported by a fund of the National Nature Science (30900238).

Conflict of interest

The authors declare that they have no competing interests.

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Authors and Affiliations

  1. Stomatological Department, Qingdao Municipal Hospital, Qingdao, 266011, China

    Shulai Lu

  2. Department of Biochemistry and Molecular Biology, The University of Texas Medical School at Houston, Houston, TX, 77030, USA

    Zhimin Miao, Weiting Guo, Wenshan Lv, Changgui Li, Yangang Wang, Shihua Zhao, Shengli Yan, Zhenyin Tao & Yunlong Wang

  3. Gout laboratory, The Affiliated Hospital of Medical College Qingdao University, Shandong Provincial Key Laboratory Of Metabolic Diseases, 16 Jiangsu Road, Qingdao, 266003, People’s Republic of China

    Zhimin Miao, Weiting Guo, Wenshan Lv, Changgui Li, Yangang Wang, Shihua Zhao, Shengli Yan & Yunlong Wang

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  1. Zhimin Miao
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Correspondence to Zhenyin Tao or Yunlong Wang.

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Zhimin Miao, Weiting Guo and Shulai Lu are contributed equally to this work.

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Miao, Z., Guo, W., Lu, S. et al. Hypothermia induced by adenosine 5′-monophosphate attenuates early stage injury in an acute gouty arthritis rat model. Rheumatol Int 33, 2085–2092 (2013). https://doi.org/10.1007/s00296-013-2676-5

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  • DOI: https://doi.org/10.1007/s00296-013-2676-5

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