Abstract
Objective
The aim of this study was to determine the clinical and genetic risk factors that influence herpes zoster occurrence in patients with systemic lupus erythematosus (SLE).
Methods
Three hundred three SLE patients meeting the American College of Rheumatology criteria were enrolled in this study. Herpes zoster was diagnosed when classic grouped vesicles were noted. Medical records were reviewed retrospectively to collect clinical information. For Fc gamma receptor IIa (FcγRIIa) and FcγRIIIa genoty**, polymerase chain reaction (PCR) using allele-specific primers was performed. The PCR sequence-specific oligonucleotide probe method was utilized in human HLA-DRB1 genoty**.
Results
Forty-two cases (13.9%) of zoster occurred among 303 SLE patients. The incidence of zoster in patients with SLE was 32.5/1,000 patients per year. Patients who developed zoster had higher rates of lupus nephritis (P=0.018) and positive anti-Sm antibody (P=0.019). However, FcγRIIa and FcγRIIIa polymorphism and the HLA-DRB1 genotype did not influence herpes zoster occurrence.
Conclusion
Systemic lupus erythematosus patients with lupus nephritis or anti-Sm antibody are at higher risk of herpes zoster. FcγRIIa (H/R131), FcγRIIIa (F/V176), and HLA-DRB1 genetic polymorphisms did not influence the occurrence of herpes zoster in these patients.
Similar content being viewed by others
References
Choo PW, Donahue JG, Manson JE, Platt R (1995) The epidemiology of Varicella and its complications. J Infect Dis 172:706–712
Nagasawa K, Yamauchi Y, Tada Y, Kusaba T, Niho Y, Yoshikawa H (1990) High incidence of herpes zoster in patients with systemic lupus erythematosus: an immunological analysis. Ann Rheum Dis 49:630–633
Grose C, Litwin V (1988) Immunology of the Varicella-zoster virus glycoproteins. J Infect Dis 157:877–881
Ogata M, Shigeta S (1979) Appearance of immunoglobulin G Fc receptor in cultured human cells infected with Varicella-zoster virus. Infect Immun 26:770–774
Clark MR, Clarkson SB, Ory PA, Stollman N, Goldstein IM (1989) Molecular basis for a polymorphism involving Fc receptor II on human monocytes. J Immunol 143:1731–1734
Warmerdam PA, van de Winkel JG, Gosselin EJ, Capel PJ (1990) Molecular basis for a polymorphism of human Fc gamma receptor II (CD32). J Exp Med 172:19–25
Salmon JE, Edberg JC, Brogle NL, Kimberly RP (1992) Allelic polymorphisms of human Fc gamma receptor IIA and Fc gamma receptor IIIB. Independent mechanisms for differences in human phagocyte function. J Clin Invest 89:1274–1281
Warmerdam PA, van de Winkel JG, Vlug A, Westerdaal NA, Capel PJ (1991) A single amino acid in the second Ig-like domain of the human Fc gamma receptor II is critical for human IgG2 binding. J Immunol 147:1338–1343
Sanders LA, van de Winkel JG, Rijkers GT, Voorhorst-Ogink MM, de Haas M, Capel PJ, Zegers BJ (1994) Fc gamma receptor IIa (CD32) heterogeneity in patients with recurrent bacterial respiratory tract infections. J Infect Dis 170:854–861
Bredius RG, Derkx BH, Fijen CA, de Wit TP, de Haas M, Weening RS, van de Winkel JG, Out TA (1994) Fc gamma receptor IIa (CD32) polymorphism in fulminant meningococcal septic shock in children. J Infect Dis 170:848–853
Duits AJ, Bootsma H, Derksen RH, Spronk PE, Kater L, Kallenberg CG, Capel PJ, Westerdaal NA, Spierenburg GT, Gmelig-Meyling FH et al (1995) Skewed distribution of IgG Fc receptor IIa (CD32) polymorphism is associated with renal disease in systemic lupus erythematosus patients. Arthritis Rheum 38:1832–1836
Botto M, Theodoridis E, Thompson EM, Beynon HL, Briggs D, Isenberg DA, Walport MJ, Davies KA (1996) Fc gamma RIIa polymorphism in systemic lupus erythematosus (SLE): no association with disease. Clin Exp Immunol 104:264–268
Radeke HH, Gessner JE, Uciechowski P, Magert HJ, Schmidt RE, Resch K (1994) Intrinsic human glomerular mesangial cells can express receptors for IgG complexes (hFc gamma RIII-A) and the associated Fc epsilon RI gamma chain. J Immunol 153:1281–1292
Abendroth A, Slobedman B, Lee E, Mellins E, Wallace M, Arvin AM (2000) Modulation of major histocompatibility class II protein expression by Varicella-zoster virus. J Virol 74:1900–1907
Donahue JG, Choo PW, Manson JE, Platt R (1995) The incidence of herpes zoster. Arch Intern Med 155:1605–1609
Ragozzino MW, Melton LJ III, Kurland LT, Chu CP, Perry HO (1982) Population-based study of herpes zoster and its sequelae. Medicine (Baltimore) 61:310–316
Vachtenheim J, Grossmann J (1965) The herpetic viral diseases and systemic lupus erythematosus. Pol Tyg Lek 20:1854–1856
Moutsopoulos HM, Gallagher JD, Decker JL, Steinberg AD (1978) Herpes zoster in patients with systemic lupus erythematosus. Arthritis Rheum 21:798–802
Manzi S, Kuller LH, Kutzer J, Pazin GJ, Sinacore J, Medsger TA Jr, Ramsey-Goldman R (1995) Herpes zoster infection in systemic lupus erythematosus. J Rheumatol 22:1254–1258
Burgoon CF, Brugoon JS, Baldrige GD (1957) The natural history of herpes zoster. JAMA 164:265–269
Weller TH (1983) Varicella and herpes zoster: changing concepts of the natural history, control, and importance of a not-so-benign virus (first of two parts). N Engl J Med 309:1362–1368
Kamiya H, Ihara T, Hattori A et al (1977) Diagnostic skin test reactions with Varicella virus antigen and clinical applications of the test. J Infect Dis 136:784–788
Bruke BL, Steele RW, Beard OW, Wood JS, Cain TD, Marmer DJ (1982) Immune responses to Varicella-zoster in the aged. Arch Intern Med 142:291–293
Notman DD, Kurata N, Tan EM (1975) Profiles of antinuclear antibodies in systemic rheumatic diseases. Ann Intern Med 83:464–469
Janwityanuchit S, Verasertniyom O, Vanichapuntu M, Vatanasuk M (1993) Anti-Sm: its predictive value in systemic lupus erythematosus. Clin Rheumatol 12: 350–353
Elkon KB (2000) Autoantibodies in SLE. In: Klippel JH, Dieppe PA (eds) Rheumatology. 2nd edn. Mosby, London, pp 7.5.1–7.5.10
Huong DLT, Papo T, Beaufils H et al (1999) Renal involvement in systemic lupus erythematosus. A study of 180 patients from a single center. Medicine 72:209–220
Fessler BJ (2000) Assessing disease activity and outcome in systemic lupus erythematosus. In: Klippel JH, Dieppe PA (eds) Rheumatology. 2nd edn. Mosby, London, pp 7.8.5–7.8.6
Principato MA, Thompson GS, Friedman SM (1983) cloned major histocompatibility complex-restricted trinitrophenyl-reactive human helper T cell line that activates B cell subsets via two distinct pathways. J Exp Med 158:1444–1458
Goodman JW, Parslow TG (1994) Immunoglobulin proteins. In: Stites DP, Terr AI, Parslow TG (eds) Basic and clinical immunology. 8th edn. Appleton and Lange, Connecticut, pp 74–75
Salmon JE, Millard S, Schachter LA, Arnett FC, Ginzler EM, Gourley MF, Ramsey-Goldman R, Peterson MG, Kimberly RP (1996) Fc gamma RIIA alleles are heritable risk factors for lupus nephritis in African Americans. J Clin Invest 97:1348–1354
Manger K, Repp R, Jansen M, Geisselbrecht M, Wassmuth R, Westerdaal NA, Pfahlberg A, Manger B, Kalden JR, van de Winkel JG (2002) Fc gamma receptor IIa, IIIa, and IIIb polymorphisms in German patients with systemic lupus erythematosus: association with clinical symptoms. Ann Rheum Dis 61:786–792
Author information
Authors and Affiliations
Corresponding author
Rights and permissions
About this article
Cite this article
Kang, TY., Lee, HS., Kim, TH. et al. Clinical and genetic risk factors of herpes zoster in patients with systemic lupus erythematosus. Rheumatol Int 25, 97–102 (2005). https://doi.org/10.1007/s00296-003-0403-3
Received:
Accepted:
Published:
Issue Date:
DOI: https://doi.org/10.1007/s00296-003-0403-3