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The recent development of silk fibroin in angiogenesis

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Abstract

Silk fibroin (SF) has been utilized in various applications, including as, in bone, cartilage, nerve, skin regeneration, owing to its biocompatibility, controllable biodegradability, minimal inflammation, and tunable mechanical properties. Excellent neovascularization of silk matrices is prerequisite for the success of promoting wound healing in different tissues. Neovascularization of SF can provide a nutrient supply to the newly developed granulation tissue at the wound site and accelerate vessel formation and remodeling. In this review, we summarize the neovascularization of SF in different forms and dissolution by recombining different composites, modifying active peptides, and adding growth factors in the treatment of various wound healing processes.

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  1. College of Textile and Clothing Engineering of Soochow University, Suzhou, China

    Huiyan Shao

  2. School of Biology and Basic Medical Science, Soochow University, Suzhou, 215002, China

    Ziling Sun

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Shao, H., Sun, Z. The recent development of silk fibroin in angiogenesis. Polym. Bull. 81, 3759–3779 (2024). https://doi.org/10.1007/s00289-023-04958-4

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