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Preparation of FK-SA conjugate gel beads with double cross-linking for pH-controllable drug releasing

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Abstract

Using feather keratin (FK), a kind of biocompatible natural polymer being extracted from widely available and renewable waste feathers, and sodium alginate (SA) as materials, the FK conjugated SA gel beads (FK-SA-Gbs) were prepared with double cross-linked by calcium ion (Ca2+) and 1-ethyl-3-(3-dimethylaminopropyl) carbodiimide hydrochloride (EDC). After being characterized and analyzed by Fourier transform infrared spectroscopy (FT-IR), scanning electron microscopy (SEM), energy dispersive spectroscopy (EDS), and X-ray diffraction (XRD), its pH responsiveness, salt ion responsiveness, and degradability were measured, and the loading capacity of model drug Rhodamine B (RhB) under various physical conditions, the cumulative release rate of the loaded gel beads in different pH buffer solutions were also investigated. The results showed that the FK-SA-Gbs had significant pH sensitivity and sustained release, and various physical conditions can meet the requirements of wound dressings. It indicated FK-SA-Gbs can be used as controlled release drug carriers and are expected to be used as drug carrier materials in biomedical applications.

Graphical abstract

FK conjugated SA gel beads (FK-SA-Gbs) was prepared by secondary cross-linking with CaCl2 and 1-ethyl-3- (3-dimethylaminopropyl) carbodiimide hydrochloride (EDC/HCl) using feather keratin (FK) extracted from waste feathers, which have significant pH sensitivity and sustained release capability.

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Acknowledgements

The project was supported by the National Natural Science Foundation of China (Grant No. 21865030).

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  1. Zejun Wang and Jiarui Ren are co-first authors of the article.

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  1. Key Lab. Eco-Functional Polymer Materials of MOE, Institute of Polymer, College of Chemistry and Chemical Engineering, Northwest Normal University, Lanzhou, 730070, China

    Zejun Wang, Jiarui Ren, Lizhong Qian, Yufeng He, Pengfei Song & Rongmin Wang

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  1. Zejun Wang
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Correspondence to Yufeng He or Rongmin Wang.

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Wang, Z., Ren, J., Qian, L. et al. Preparation of FK-SA conjugate gel beads with double cross-linking for pH-controllable drug releasing. Polym. Bull. 80, 331–347 (2023). https://doi.org/10.1007/s00289-022-04076-7

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  • DOI: https://doi.org/10.1007/s00289-022-04076-7

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