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Autophagy, a novel target for chemotherapeutic intervention of thyroid cancer

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Cancer Chemotherapy and Pharmacology Aims and scope Submit manuscript

Abstract

Purpose

Thyroid cancers with unsatisfactory curative effect nowadays are the most common malignant tumors of the endocrine system. Apoptosis evasion, a hallmark of cancer, has driven the search of stimulating novel cell death way in cancer therapy. This review aims to explore the relationship between autophagy and thyroid cancer, especially the chemotherapy agents which are based on autophagy in treating thyroid cancers.

Methods

A computerized literature search of MEDLINE was performed using the following search terms: autophagy and thyroid cancer.

Results

Recent studies have found that several chemotherapeutic agents and knockdown of specific microRNA may contribute to autophagic tumor cell death in most thyroid cancer types.

Conclusions

Stimulating autophagy may be an effective alternative treatment to most types of thyroid cancer.

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Abbreviations

PTC:

Papillary thyroid cancer

FTC:

Follicular thyroid cancer

ATC:

Anaplastic thyroid cancer

MTC:

Medullary thyroid cancer

mTOR:

Mammalian target of rapamycin

mTORC:

mTOR complex

ULK:

Unc-151-like kinase

UVRAG:

Ultraviolet radiation resistance-associated gene

ATG:

Autophagy gene

PAS:

Pre-autophagosomal structure

DAPK:

Death-associated protein kinase

DRAM:

Damage-regulated autophagy modulator

PI3KCIII:

Class III phosphatidylinositol 3-kinase

ROS:

Reactive oxygen species

CA4P:

Combretastatin A4 phosphate

AMPK:

Adenosine 5′-monophosphate-activated protein kinase

ULK:

The mammalian uncoordinated-51-like protein kinase

RAD001:

Everolimus or afinitor

TSC:

Tuberous sclerosis protein

SMTC:

Spontaneous medullary thyroid cancer

HMTC:

Hereditary medullary thyroid cancer

MiRNA:

MicroRNA

RET:

Ret proto-oncogene

TKIs:

Tyrosine kinase inhibitors

LC3:

Microtubule-associated protein 1 light chain 3

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  1. The First Affiliated Hospital of Harbin Medical University, No. 23, Youzheng Street, Nangang District, Harbin, Heilongjiang province, China

    Le-chen Li, Guo-dong Liu, **n-jie Zhang & Yan-bo Li

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  1. Le-chen Li
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  2. Guo-dong Liu
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  3. **n-jie Zhang
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  4. Yan-bo Li
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Correspondence to Yan-bo Li.

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Li, Lc., Liu, Gd., Zhang, Xj. et al. Autophagy, a novel target for chemotherapeutic intervention of thyroid cancer. Cancer Chemother Pharmacol 73, 439–449 (2014). https://doi.org/10.1007/s00280-013-2363-y

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  • DOI: https://doi.org/10.1007/s00280-013-2363-y

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