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Acute myeloid leukemia with a cryptic NUP98/PRRX2 rearrangement develo** after low-dose methotrexate therapy for rheumatoid arthritis

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References

  1. Struski S, Lagarde S, Bories P, Puiseux C, Prade N, Cuccuini W, Pages MP, Bidet A, Gervais C, Lafage-Pochitaloff M, Roche-Lestienne C, Barin C, Penther D, Nadal N, Radford-Weiss I, Collonge-Rame MA, Gaillard B, Mugneret F, Lefebvre C, Bart-Delabesse E, Petit A, Leverger G, Broccardo C, Luquet I, Pasquet M, Delabesse E (2017) NUP98 is rearranged in 3.8% of pediatric AML forming a clinical and molecular homogenous group with a poor prognosis. Leukemia 31(3):565–572. https://doi.org/10.1038/leu.2016.267

    Article  PubMed  CAS  Google Scholar 

  2. Gervais C, Mauvieux L, Perrusson N, Helias C, Struski S, Leymarie V, Lioure B, Lessard M (2005) A new translocation t(9;11)(q34;p15) fuses NUP98 to a novel homeobox partner gene, PRRX2, in a therapy-related acute myeloid leukemia. Leukemia 19(1):145–148. https://doi.org/10.1038/sj.leu.2403565

    Article  PubMed  CAS  Google Scholar 

  3. Romana SP, Radford-Weiss I, Ben Abdelali R, Schluth C, Petit A, Dastugue N, Talmant P, Bilhou-Nabera C, Mugneret F, Lafage-Pochitaloff M, Mozziconacci MJ, Andrieu J, Lai JL, Terre C, Rack K, Cornillet-Lefebvre P, Luquet I, Nadal N, Nguyen-Khac F, Perot C, Van den Akker J, Fert-Ferrer S, Cabrol C, Charrin C, Tigaud I, Poirel H, Vekemans M, Bernard OA, Berger R, Groupe Francophone de Cytogenetique H (2006) NUP98 rearrangements in hematopoietic malignancies: a study of the Groupe Francophone de Cytogenetique Hematologique. Leukemia 20(4):696–706. https://doi.org/10.1038/sj.leu.2404130

    Article  PubMed  CAS  Google Scholar 

  4. Pointud P, Prudat M, Peron JM (1993) Acute leukemia after low dose methotrexate therapy in a patient with rheumatoid arthritis. J Rheumatol 20(7):1215–1216

    PubMed  CAS  Google Scholar 

  5. Tanaka K, Oshikawa G, Akiyama H, Ishida S, Nagao T, Yamamoto M, Miura O (2017) Acute myeloid leukemia with t(3;21)(q26.2;q22) develo** following low-dose methotrexate therapy for rheumatoid arthritis and expressing two AML1/MDS1/EVI1 fusion proteins: A case report. Oncol Lett 14(1):97–102. https://doi.org/10.3892/ol.2017.6151

    Article  PubMed  PubMed Central  CAS  Google Scholar 

  6. Hollink IH, van den Heuvel-Eibrink MM, Arentsen-Peters ST, Pratcorona M, Abbas S, Kuipers JE, van Galen JF, Beverloo HB, Sonneveld E, Kaspers GJ, Trka J, Baruchel A, Zimmermann M, Creutzig U, Reinhardt D, Pieters R, Valk PJ, Zwaan CM (2011) NUP98/NSD1 characterizes a novel poor prognostic group in acute myeloid leukemia with a distinct HOX gene expression pattern. Blood 118(13):3645–3656. https://doi.org/10.1182/blood-2011-04-346643

    Article  PubMed  CAS  Google Scholar 

  7. Ostronoff F, Othus M, Gerbing RB, Loken MR, Raimondi SC, Hirsch BA, Lange BJ, Petersdorf S, Radich J, Appelbaum FR, Gamis AS, Alonzo TA, Meshinchi S (2014) NUP98/NSD1 and FLT3/ITD coexpression is more prevalent in younger AML patients and leads to induction failure: a COG and SWOG report. Blood 124(15):2400–2407. https://doi.org/10.1182/blood-2014-04-570929

    Article  PubMed  PubMed Central  CAS  Google Scholar 

  8. Reader JC, Meekins JS, Gojo I, Ning Y (2007) A novel NUP98-PHF23 fusion resulting from a cryptic translocation t(11;17)(p15;p13) in acute myeloid leukemia. Leukemia 21(4):842–844. https://doi.org/10.1038/sj.leu.2404579

    Article  PubMed  CAS  Google Scholar 

  9. de Rooij JD, Hollink IH, Arentsen-Peters ST, van Galen JF, Berna Beverloo H, Baruchel A, Trka J, Reinhardt D, Sonneveld E, Zimmermann M, Alonzo TA, Pieters R, Meshinchi S, van den Heuvel-Eibrink MM, Zwaan CM (2013) NUP98/JARID1A is a novel recurrent abnormality in pediatric acute megakaryoblastic leukemia with a distinct HOX gene expression pattern. Leukemia 27(12):2280–2288. https://doi.org/10.1038/leu.2013.87

    Article  PubMed  CAS  Google Scholar 

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Funding

This work was supported by grants from the Project for Cancer Research and Therapeutic Evolution (P-CREATE) (19cm0106235h0002) and the Acceleration Program for Intractable Diseases Research utilizing Disease-specific iPS cells (19bm0804004h0003) of the Japan Agency for Medical Research and Development.

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Correspondence to Kazuhisa Chonabayashi.

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Chonabayashi, K., Yoshida, Y., Kitawaki, T. et al. Acute myeloid leukemia with a cryptic NUP98/PRRX2 rearrangement develo** after low-dose methotrexate therapy for rheumatoid arthritis. Ann Hematol 98, 2841–2843 (2019). https://doi.org/10.1007/s00277-019-03838-0

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