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Magnetic Resonance Imaging of Acute Reperfused Myocardial Infarction: Intraindividual Comparison of ECIII-60 and Gd-DTPA in a Swine Model

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Abstract

Purpose

To compare a necrosis-avid contrast agent (NACA) bis-Gd-DTPA-pamoic acid derivative (ECIII-60) after intracoronary delivery with an extracellular agent Gd-DTPA after intravenous injection on magnetic resonance imaging (MRI) in a swine model of acute reperfused myocardial infarction (MI).

Methods

Eight pigs underwent 90 min of transcatheter coronary balloon occlusion and 60 min of reperfusion. After intravenous injection of Gd-DTPA at a dose of 0.2 mmol/kg, all pigs were scanned with T1-weighted MRI until the delayed enhancement of MI disappeared. Then they were intracoronarily infused with ECIII-60 at 0.0025 mmol/kg and imaged for 5 hr. Signal intensity, infarct-over-normal contrast ratio and relative infarct size were quantified, compared, and correlated with the results of postmortem MRI and triphenyltetrazolium chloride (TTC) histochemical staining.

Results

A contrast ratio over 3.0 was induced by both Gd-DTPA and ECIII-60. However, while the delayed enhancement with Gd-DTPA virtually vanished in 1 hr, ECIII-60 at an 80× smaller dose depicted the MI accurately over 5 hr as proven by ex vivo MRI and TTC staining.

Conclusion

Both Gd-DTPA and ECIII-60 strongly enhanced acute MI. Comparing with fading contrast in a narrow time window with intravenous Gd-DTPA, intracoronary ECIII-60 persistently demarcated the acute MI, indicating a potential method for postprocedural assessment of myocardial viability after coronary interventions.

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Acknowledgments

This project is partially supported by a grant from the Scientifc And Technologic Fund (XJ 0590217) of Southeast University, Nan**g, China, and by the research fund of Ondersoeksfonds OT/96/33, University of Leuven, Belgium. We thank **ming Wei, PhD, Department of Statistics, School of Basic Medical Sciences, Southeast University, Nan**g, China, for his advice on the statistical analysis of the data.

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Authors and Affiliations

  1. Department of Radiology, Zhongda Hospital of Southeast University, Nan**g, China

    Jiyang **, Gaojun Teng, Qindi **, Qin Lu, Shengqi Wang & Feng Chen

  2. Department of Cardiology, Zhongda Hospital of Southeast University, Nan**g, China

    Yi Feng, Yan** Wu, Yu Wang & Yibo Jiang

  3. Department of Anaesthesiology, Zhongda Hospital of Southeast University, Nan**g, China

    Zhen Wang

  4. Department of Radiology, University Hospitals, University of Leuven, Herestraat 49, 3000, Leuven, Belgium

    Feng Chen, Guy Marchal & Yicheng Ni

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  1. Jiyang **
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Correspondence to Yicheng Ni.

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**, J., Teng, G., Feng, Y. et al. Magnetic Resonance Imaging of Acute Reperfused Myocardial Infarction: Intraindividual Comparison of ECIII-60 and Gd-DTPA in a Swine Model. Cardiovasc Intervent Radiol 30, 248–256 (2007). https://doi.org/10.1007/s00270-006-0004-0

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