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Advances in stent therapy for malignant biliary obstruction

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Abstract

Malignant biliary obstruction (MBO), result of pancreatobiliary diseases is a challenging condition. Most patients with MBO are inoperable at the time of diagnosis, and the disease is poorly controlled using external-beam radiotherapy and chemotherapy. Biliary stent therapy emerged as a promising strategy for alleviating MBO and prolonging life. However, physicians find it difficult to determine the optimal type of biliary stent for the palliation of MBO. Here, we review the safety and efficacy of available biliary stents, used alone or in combination with brachytherapy, photodynamic therapy and advanced chemotherapeutics, in patients with pancreatobiliary malignancies and put forward countermeasures involving stent obstruction. Furthermore, 3D-printing stents and nanoparticle-loaded stents have broad application prospects for fabricating tailor-made biliary stents.

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  1. **n He and Ying Zhu have contributed equally to this work.

Authors and Affiliations

  1. Department of Gastroenterology, The First Affiliated Hospital of Nanchang University, Nanchang, 330006, Jiangxi, China

    **n He, Ying Zhu, Yining Wang, Yuanzhen Hao & Junbo Hong

  2. Key Laboratory of Carcinogenesis and Cancer Invasion (Ministry of Education), Department of Liver Surgery and Transplantation, Zhongshan Hospital, Liver Cancer Institute, Fudan University, Shanghai, 200032, China

    Yining Wang

  3. Joint Program of Nanchang University and Queen Mary University of London, Nanchang, 330006, China

    Yining Wang & Yuanzhen Hao

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  1. **n He
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JH raised conception and design of the current literature; XH concentrated on data analysis and interpretation, provision of study materials or patients; YZ was devoted in data analysis and interpretation, provision of study materials or patients with XH; YW, together with YH, put collection and assembly of data into practice. And for all of the authors had contributed to the stage of final approval of manuscript and manuscript writing.

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Correspondence to Junbo Hong.

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He, X., Zhu, Y., Wang, Y. et al. Advances in stent therapy for malignant biliary obstruction. Abdom Radiol 46, 351–361 (2021). https://doi.org/10.1007/s00261-020-02593-5

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