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Review of imaging recommendations from Response Assessment in Pediatric Neuro-Oncology (RAPNO)

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Abstract

The Response Assessment in Pediatric Neuro-Oncology (RAPNO) working group includes neuroradiologists, neuro-oncologists, neurosurgeons, radiation oncologists, and clinicians in various additional specialties. This review paper will summarize the imaging recommendations from RAPNO for the six RAPNO publications to date covering pediatric low-grade glioma, pediatric high-grade glioma, medulloblastoma and other leptomeningeal seeding tumors, diffuse intrinsic pontine glioma, ependymoma, and craniopharyngioma.

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Data availability

The datasets generated and/or analyzed during the current study are available from the corresponding author on reasonable request.

Data sharing

No data were generated or analyzed during the study.

References

  1. Erker C, Tamrazi B, Poussaint TY et al (2020) Response assessment in paediatric high-grade glioma: recommendations from the Response Assessment in Pediatric Neuro-Oncology (RAPNO) working group. Lancet Oncol 21:e317–e329. https://doi.org/10.1016/S1470-2045(20)30173-X

    Article  CAS  PubMed  Google Scholar 

  2. Cooney TM, Cohen KJ, Guimaraes CV et al (2020) Response assessment in diffuse intrinsic pontine glioma: recommendations from the Response Assessment in Pediatric Neuro-Oncology (RAPNO) working group. Lancet Oncol 21:e330–e336. https://doi.org/10.1016/S1470-2045(20)30166-2

    Article  PubMed  Google Scholar 

  3. Fangusaro J, Witt O, Hernáiz Driever P et al (2020) Response assessment in paediatric low-grade glioma: recommendations from the Response Assessment in Pediatric Neuro-Oncology (RAPNO) working group. Lancet Oncol 21:e305–e316. https://doi.org/10.1016/S1470-2045(20)30064-4

    Article  PubMed  Google Scholar 

  4. Warren KE, Vezina G, Poussaint TY et al (2018) Response assessment in medulloblastoma and leptomeningeal seeding tumors: recommendations from the Response Assessment in Pediatric Neuro-Oncology committee. Neuro Oncol 20:13–23. https://doi.org/10.1093/neuonc/nox087

    Article  CAS  PubMed  Google Scholar 

  5. Lindsay HB, Massimino M, Avula S et al (2022) Response assessment in paediatric intracranial ependymoma: recommendations from the Response Assessment in Pediatric Neuro-Oncology (RAPNO) working group. Lancet Oncol 23:e393–e401. https://doi.org/10.1016/S1470-2045(22)00222-4

    Article  PubMed  Google Scholar 

  6. Hoffman LM, Jaimes C, Mankad K et al (2023) Response assessment in pediatric craniopharyngioma: recommendations from the Response Assessment in Pediatric Neuro-Oncology (RAPNO) Working Group. Neuro Oncol 25:224–233. https://doi.org/10.1093/neuonc/noac221

    Article  PubMed  Google Scholar 

  7. Osborn AG, Louis DN, Poussaint TY et al (2022) The 2021 World Health Organization Classification of Tumors of the Central Nervous System: what neuroradiologists need to know. AJNR Am J Neuroradiol 43:928–937. https://doi.org/10.3174/ajnr.A7462

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  8. Louis DN, Perry A, Wesseling P et al (2021) The 2021 WHO Classification of Tumors of the Central Nervous System: a summary. Neuro Oncol 23:1231–1251. https://doi.org/10.1093/neuonc/noab106

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  9. Milde T, Rodriguez FJ, Barnholtz-Sloan JS et al (2021) Reimagining pilocytic astrocytomas in the context of pediatric low-grade gliomas. Neuro Oncol 23:1634–1646. https://doi.org/10.1093/neuonc/noab138

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  10. Leach JL, Roebker J, Schafer A et al (2020) MR imaging features of diffuse intrinsic pontine glioma and relationship to overall survival: report from the International DIPG Registry. Neuro Oncol 22:1647–1657. https://doi.org/10.1093/neuonc/noaa140

    Article  PubMed  PubMed Central  Google Scholar 

  11. Makepeace L, Scoggins M, Mitrea B et al (2020) MRI patterns of extrapontine lesion extension in diffuse intrinsic pontine gliomas. AJNR Am J Neuroradiol 41:323–330. https://doi.org/10.3174/ajnr.A6391

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  12. Sartoretti-Schefer S, Wichmann W, Aguzzi A, Valavanis A (1997) MR differentiation of adamantinous and squamous-papillary craniopharyngiomas. AJNR Am J Neuroradiol 18:77–87

    CAS  PubMed  PubMed Central  Google Scholar 

  13. McCrea HJ, George E, Settler A et al (2016) Pediatric suprasellar tumors. J Child Neurol 31:1367–1376. https://doi.org/10.1177/0883073815620671

    Article  PubMed  Google Scholar 

  14. Skipworth JRA, Hill CS, Jones T et al (2012) Pilocytic astrocytoma mimicking craniopharyngioma: a case series. Ann R Coll Surg Engl 94:e125–e128. https://doi.org/10.1308/003588412X13171221588811

    Article  CAS  PubMed  PubMed Central  Google Scholar 

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Acknowledgements

Thank you to Dr. Laura De Leon Benedetti on contributing to the construction of the figures and tables in this paper.

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Authors and Affiliations

  1. Department of Radiology, Children’s Hospital of Philadelphia, 3401 Civic Center Blvd, Philadelphia, PA, 19104, USA

    Aashim Bhatia, Noah D. Sabin, Michael J. Fisher & Tina Young Poussaint

  2. Department of Diagnostic Imaging, St. Jude Children’s Research Hospital, Memphis, TN, USA

    Noah D. Sabin

  3. Division of Oncology, Department of Pediatrics , Children’s Hospital of Philadelphia, University of Pennsylvania, Perelman School of Medicine, Philadelphia, PA, USA

    Michael J. Fisher

  4. Department of Radiology, Boston Children’s Hospital and Harvard Medical School, Boston, MA, USA

    Tina Young Poussaint

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  1. Aashim Bhatia
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  2. Noah D. Sabin
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  4. Tina Young Poussaint
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Correspondence to Aashim Bhatia.

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Conflicts of interest

Aashim Bhatia reports no disclosures relevant to the manuscript (consultant for Guerbet).

Noah D. Sabin: None.

Michael J. Fisher: None.

Tina Young Poussaint: None.

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Bhatia, A., Sabin, N.D., Fisher, M.J. et al. Review of imaging recommendations from Response Assessment in Pediatric Neuro-Oncology (RAPNO). Pediatr Radiol 53, 2723–2741 (2023). https://doi.org/10.1007/s00247-023-05780-w

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  • DOI: https://doi.org/10.1007/s00247-023-05780-w

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