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Grading of supratentorial astrocytic tumors by using the difference of ADC value

  • Functional Neuroradiology
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Abstract

Introduction

To investigate the application value of diffusion-weighted imaging (DWI), the difference of apparent diffusion coefficient (ADCdifference) value calculated from ADCdifference map was used, in evaluating the pathologic grade of astrocytic tumors.

Methods

33 patients with histopathologically proven supratentorial astrocytic tumors were included in this prospective study. All of them received conventional magnetic resonance imaging (MRI), DWI with diffusion factor of 0 and 50 s/mm2 and of 0 and 3,000 s/mm2, and perfusion-weighted imaging (PWI) examinations. Pseudo-color ADCdifference maps were obtained by means of using ADC map with low b value (0 and 50 s/mm2) minus ADC map with high b value (0 and 3,000 s/mm2).

Results

The highest ADCdifference value of grades I–II, grade III, and grade IV was (0.91 ± 0.07) × 10−3, (1.81 ± 0.38) × 10−3, and (2.36 ± 0.32) × 10−3 mm2/s, respectively, and there was statistical difference among them (p < 0.001). The highest ADCdifference value between low-grade (grades I–II) and high-grade (grades III–IV) astrocytic tumors showed statistical difference as well (p < 0.001). The highest ADCdifference value of astrocytic tumors correlated positively with the pathologic grade of tumor (r = 0.853, p < 0.001). Positive correlation was found between the highest ADCdifference value and maximum relative cerebral blood volume (rCBV) value (r = 0.829, p < 0.001) in high-grade astrocytic tumors; however, the highest ADCdifference value and maximum rCBV value had no significant correlation in low-grade astrocytic tumors (r = 0.259, p = 0.536).

Conclusion

Quantitative analysis of highest ADCdifference value of supratentorial astrocytic tumors may provide valuable information of tumor microcirculation and perfusion, thus allowing a promising new method for preoperatively assessing the pathologic grade of tumor.

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We declare that we have no conflict of interest.

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Authors and Affiliations

  1. Department of Radiology, Tian** Huanhu Hospital, Tian**, China

    Xu Bai, Tong Han & Li Liu

  2. Department of Radiology, General Hospital of Tian** Medical University, Tian**, China

    Yunting Zhang

  3. Department of Radiology, Key Laboratory of Cancer Prevention and Therapy, Tian** Medical University Cancer Institute and Hospital, Tian**, China

    Ying Liu

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  1. Xu Bai
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  2. Yunting Zhang
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Correspondence to Ying Liu.

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Bai, X., Zhang, Y., Liu, Y. et al. Grading of supratentorial astrocytic tumors by using the difference of ADC value. Neuroradiology 53, 533–539 (2011). https://doi.org/10.1007/s00234-011-0846-2

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