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Assessment of Bone Microarchitecture in Chronic Kidney Disease: A Comparison of 2D Bone Texture Analysis and High-Resolution Peripheral Quantitative Computed Tomography at the Radius and Tibia

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Abstract

Bone microarchitecture can be studied noninvasively using high-resolution peripheral quantitative computed tomography (HR-pQCT). However, this technique is not widely available, so more simple techniques may be useful. BMA is a new 2D high-resolution digital X-ray device, allowing for bone texture analysis with a fractal parameter (Hmean). The aims of this study were (1) to evaluate the reproducibility of BMA at two novel sites (radius and tibia) in addition to the conventional site (calcaneus), (2) to compare the results obtained with BMA at all of those sites, and (3) to study the relationship between Hmean and trabecular microarchitecture measured with an in vivo 3D device (HR-pQCT) at the distal tibia and radius. BMA measurements were performed at three sites (calcaneus, distal tibia, and radius) in 14 healthy volunteers to measure the short-term reproducibility and in a group of 77 patients with chronic kidney disease to compare BMA results to HR-pQCT results. The coefficient of variation of Hmean was 1.2, 2.1, and 4.7% at the calcaneus, radius, and tibia, respectively. We found significant associations between trabecular volumetric bone mineral density and microarchitectural variables measured by HR-pQCT and Hmean at the three sites (e.g., Pearson correlation between radial trabecular number and radial Hmean r = 0.472, P < 0.001). This study demonstrated a significant but moderate relationship between 2D bone texture and 3D trabecular microarchitecture. BMA is a new reproducible technique with few technical constraints. Thus, it may represent an interesting tool for evaluating bone structure, in association with biological parameters and DXA.

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Acknowledgments

We thank Pr. Maurice Laville and Drs. Laurent Juillard, Fitsum Guebre-Egziabher, Nicolas Rognant, Catherine Chaubo, and Alexandre Klein (Department of Nephrology, Hôpital Edouard Herriot, Réseau TIRCEL, Lyon, France) for help in patient recruitment. We also thank Dr. Clotilde Gadois (D3A Medical Systems) for her scientific support. This work was partly supported by a 2007 Société Française de Pédiatrie/Archives de Pédiatrie educational grant.

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Authors and Affiliations

  1. Centre de Référence des Maladies Rénales Rares, Service de Néphrologie et Rhumatologie Pédiatrique, Hôpital Femme Mère Enfant, Bron, France

    Justine Bacchetta

  2. INSERM U831, Pavillon F Place d’Arsonval, 69377, Lyon Cedex 03, France

    Justine Bacchetta, Stéphanie Boutroy, Nicolas Vilayphiou, Anne Fouque-Aubert, Pierre D. Delmas & Roland Chapurlat

  3. Université de Lyon, Lyon, France

    Justine Bacchetta, Stéphanie Boutroy, Nicolas Vilayphiou, Anne Fouque-Aubert, Pierre D. Delmas, Denis Fouque & Roland Chapurlat

  4. Service de Rhumatologie, Centre Hospitalier Régional d’Orléans, Orléans, France

    Eric Lespessailles

  5. Département de Néphrologie, Hôpital Edouard Herriot, Lyon, France

    Denis Fouque

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  1. Justine Bacchetta
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Correspondence to Justine Bacchetta.

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Bacchetta, J., Boutroy, S., Vilayphiou, N. et al. Assessment of Bone Microarchitecture in Chronic Kidney Disease: A Comparison of 2D Bone Texture Analysis and High-Resolution Peripheral Quantitative Computed Tomography at the Radius and Tibia. Calcif Tissue Int 87, 385–391 (2010). https://doi.org/10.1007/s00223-010-9402-z

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  • DOI: https://doi.org/10.1007/s00223-010-9402-z

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