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Influence of host–guest interactions on analytical performance of direct analysis in real-time mass spectrometry

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Abstract

To systematically study the influence of host–guest interactions on the analytical performance of direct analysis in real time mass spectrometry (DART-MS), the interactions between cyclodextrins (CDs) and different Sudan dyes were investigated. The results showed that the host–guest interaction between CDs and Sudan dyes did not affect qualitative analysis of the target compounds, but led to a lower signal intensity for Sudan dyes, thus affecting quantitative analysis of the target compounds. The stronger the host–guest interaction, the weaker the signal intensity of target compound on DART-MS. The results also show that both in solution and in solid-phase microextraction (SPME), the addition of organic solvents can weaken the host–guest interaction between CDs and Sudan dyes, thus improving the signal intensity in DART-MS. In SPME, adding organic solvents has a certain practical value and can improve the efficiency of Sudan dye analysis. This study suggests that appropriate sample pretreatment is needed to weaken noncovalent interactions prior to DART-MS analysis to obtain more accurate quantitative results. The data provide some insight into the effects of other noncovalent interactions on the efficiency of DART-MS as an analytical tool, as well as the potential to study intermolecular interactions with DART-MS.

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Funding

This research was supported by the Jiangsu Agricultural Science and Technology Innovation Fund, China (Grant No. SCX(20)3083), the Natural Science Foundation of Hebei Province (B2018201270), and the Priority Academic Program Development of Jiangsu Higher Education Institutions, Jiangsu Collaborative Innovation Center of Biomedical Functional Materials.

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  1. M. Liu and S. Wang contributed equally to this work.

Authors and Affiliations

  1. Jiangsu Collaborative Innovation Center of Biomedical Functional Materials, Jiangsu Key Laboratory of Biomedical Materials, College of Chemistry and Materials Science, Nan**g Normal University, Nan**g, 210023, China

    Min Liu, Simin Wang, Wuxia Ge, Wentao Bi & David Da Yong Chen

  2. Department of Chemistry, University of British Columbia, Vancouver, BC, V6T 1Z1, Canada

    David Da Yong Chen

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  1. Min Liu
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Published in the topical collection Young Investigators in (Bio-)Analytical Chemistry 2023 with guest editors Zhi-Yuan Gu, Beatriz Jurado-Sánchez, Thomas H. Linz, Leandro Wang Hantao, Nongnoot Wongkaew, and Peng Wu.

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Liu, M., Wang, S., Ge, W. et al. Influence of host–guest interactions on analytical performance of direct analysis in real-time mass spectrometry. Anal Bioanal Chem 415, 4343–4352 (2023). https://doi.org/10.1007/s00216-023-04539-4

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