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One-step fabrication of COF-coated melamine sponge for in-syringe solid-phase extraction of active ingredients from traditional Chinese medicine in serum samples

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Abstract

In this study, a covalent organic framework (COF)-TpBD-supported melamine sponge (MS) was fabricated through a one-step hydrothermal method. The obtained monolithic column was then applied in in-syringe solid-phase extraction (IS-SPE) for the separation of three volatile ingredients from serum samples. Given credit for the superior adsorption capacity of the COF and the homogeneous microporous property of MS, the developed column exhibited satisfactory separation of the targets. And the dominating adsorption mechanism was the hydrophobic interaction forces between TpBD and targets and the high mass transfer efficiency provided by the large pore structure of MS. The results of dynamic adsorption showed that the MS@TpBD column displayed much better adsorption performance than blank MS and TpBD. And it has featured great reusability up to 5 cycles and obtained satisfied recovery values (87.9 ~ 110.3%) in serum samples. As a result of sample clean-up, this column offers low limit of detections (LODs) down to 0.014, 0.010, and 0.020 μg/mL, respectively. In summary, we believe that this convenient separation column has prominent application promise in the fields of separating activity ingredients in biological samples.

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Funding

This work was financially supported by the Natural Sciences Foundation of Liaoning Province (No.20180550681), the National Natural Science Foundation of China (No. 81872835), and the Young Elite Scientist Sponsorship Program of Bei**g Association for Science and Technology (2021–2023).

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Authors and Affiliations

  1. MOE Key Laboratory of Bioorganic Phosphorus Chemistry & Chemical Biology, Bei**g Key Lab of Microanalytical Methods & Instrumentation, Department of Chemistry, Tsinghua University, Bei**g, 100084, China

    Wei Wei, Zenghui Lu, Qiang Han & Qionglin Liang

  2. College of Pharmacy, Liaoning University of Traditional Chinese Medicine, Dalian, 116000, China

    Wei Wei, Ting Wu & Haibo Wang

Authors
  1. Wei Wei
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  2. Zenghui Lu
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  3. Ting Wu
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  4. Haibo Wang
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  5. Qiang Han
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  6. Qionglin Liang
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Corresponding authors

Correspondence to Haibo Wang or Qiang Han.

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Ethics approval

The animals experiments are approved by the Animal Ethics Committee of Tsinghua University and performed in compliance with the Animal Management Rules of the Ministry of Health of the People’s Republic of China (Document no. 55, 2001).

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We have taken great efforts to reduce the number of animals used in this work and also taken efforts to reduce animal suffering from pain and discomfort.

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Wei, W., Lu, Z., Wu, T. et al. One-step fabrication of COF-coated melamine sponge for in-syringe solid-phase extraction of active ingredients from traditional Chinese medicine in serum samples. Anal Bioanal Chem 414, 8071–8079 (2022). https://doi.org/10.1007/s00216-022-04340-9

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