Abstract
Studies have shown that nifedipine exerts anti-inflammatory and immunosuppressive actions in addition to being a calcium channel blocker. The present study was performed to explore the influence of nifedipine on alveolar bone destruction in mice with experimental periodontitis by evaluating morphological information acquired from micro-computed tomography analysis. BALB/c mice were randomly assigned into four groups: control (C) group; experimental periodontitis (E) group; experimental periodontitis + 10 mg/kg dose of nifedipine (EN10) group; and experimental periodontitis + 50 mg/kg dose of nifedipine (EN50) group. Periodontitis was induced by oral inoculation with Porphyromonas gingivalis over a 3-week time period. Nifedipine significantly mitigated the loss of alveolar bone height as well as increase of root surface exposure induced by experimental periodontitis. Additionally, the reduction in the bone volume fraction associated with P. gingivalis infection was significantly recovered upon nifedipine treatment. Further, nifedipine attenuated P. gingivalis-induced deteriorations in the trabeculae-associated parameters. Significant difference was evident between Groups EN10 and EN50 in both the extent of alveolar bone loss and microstructural parameters assessed, except trabecular separation and trabecular number. Nifedipine appeared to have good performance in ameliorating bone loss in mice with induced periodontitis. Nifedipine may be utilized in the clinical management of periodontitis, though further research is indicated to verify the therapeutic effect.
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The data of this study are available from the corresponding author upon reasonable request.
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This work was supported by the National Research Foundation of Korea (NRF) grant funded by the Korea government (MSIT) (2018R1A2B6006276).
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SJK, EYC and ISC designed the study, analyzed data, and wrote the manuscript. YHL, JEL and ARL carried out the experimental work and contributed to the preparation of the manuscript. All authors read and approved the manuscript. All data were generated in-house and no paper mill was used. The authors confirm that no paper mill and artificial intelligence was used.
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Lee, Y., Lee, J.E., Lee, A.R. et al. Nifedipine attenuates alveolar bone destruction and improves trabecular microarchitectures in mice with experimental periodontitis. Naunyn-Schmiedeberg's Arch Pharmacol 396, 3627–3633 (2023). https://doi.org/10.1007/s00210-023-02557-8
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DOI: https://doi.org/10.1007/s00210-023-02557-8