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Outcome of a novel porcine-derived UBM/SIS composite biological mesh in a rabbit vaginal defect model

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Abstract

Introduction and hypothesis

To investigate the tissue reactions of a novel porcine-derived urinary bladder matrix/small intestinal submucosa (UBM/SIS) biological mesh and SIS mesh implanted in a rabbit vaginal defect model.

Methods

Thirty-two rabbits were implanted with UBM/SIS mesh (Group A) and SIS mesh (Group B), respectively. Rabbits were sacrificed at 7, 14, 60, and 180 days after implantation. The tensile strength, elongation at break, and elastic modulus of the tissue were measured using biomechanical methods. The inflammatory response, cell infiltration, vascularization, and collagen fibers were observed.

Results

Compared with Group B, the tensile strength and elongation at break of group A was higher at 14, 60, and 180 days. The elastic modulus of group A was lower at 180 days. Inflammatory response of group A was milder at 14, 60, and 180 days. There was more cell infiltration in group A at 7 and 14 days. Vascularization was higher in group A at 7 days and 14 days. The order of collagen in group A was better at 14, 60, and 180 days. The proportion of thick red fibers in both groups showed an increasing trend. At 14 days, group A had more thick red fibers.

Conclusions

The novel UBM/SIS composite mesh had a milder inflammatory response; earlier induction of cell infiltration, angiogenesis, and collagen regeneration. Collagen fibers had a better order. It has a higher tensile strength and greater elongation at break, and can be used as a potential material for the treatment of pelvic organ prolapse.

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Acknowledgements

The present work was supported by Peking University Clinical Medicine +X Youth Special Project (A 82504-03)

Funding

Peking University Clinical Medicine + X Youth Special Project,A82504-03,Yiting Wang

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Authors and Affiliations

  1. Peking University Third Hospital, Haidian District, No. 49 North Garden Road, 100191, Bei**g, China

    Yiting Wang, Kun Zhang, Junfang Yang, Ying Yao, Yiqi Guan & **song Han

  2. Division of Colorectal Surgery, Changzheng Hospital, Naval Medical University, Shanghai, China

    Wenyue Cheng & Jian Zhang

Authors
  1. Yiting Wang
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  2. Kun Zhang
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  7. Jian Zhang
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  8. **song Han
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Contributions

Yiting Wang: experiments on animals, data collection, manuscript writing.

Kun Zhang: experiments on animals

Junfang Yang: experiments on animals

Ying Yao: experiments on animals

Yiqi Guan: experiments on animals

Wenyue Cheng: data collection

**song Han: project development

Jian Zhang: project development

Corresponding authors

Correspondence to Jian Zhang or **song Han.

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Wang, Y., Zhang, K., Yang, J. et al. Outcome of a novel porcine-derived UBM/SIS composite biological mesh in a rabbit vaginal defect model. Int Urogynecol J 34, 1501–1511 (2023). https://doi.org/10.1007/s00192-022-05400-5

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  • DOI: https://doi.org/10.1007/s00192-022-05400-5

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