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A 36-year-old woman was referred for the management of generalized tonic–clonic seizure. On admission, episodes of convulsions occurred that shortly turned into status epilepticus, requiring immediate resuscitation and initiation of mechanical ventilation. Although imaging studies of the brain were unremarkable, serum biochemical analyses disclosed high blood urea nitrogen 55.71 mmol/l (normal range 2.5–8.0 mmol/l) and creatinine 689.52 μmol/l (normal range 50–110 μmol/l). Nevertheless, she barely responded to intravenous infusion of sodium valproate, lorazepam and phenytoin. Considering the neurological presentations of uremia, hemodialysis was started promptly. After the first two sessions, the epileptic seizures resolved completely. Further workup incriminated a giant retroperitoneal cystic lymphangioma responsible for the post-renal component of uremia (Fig. 1). A complete tumor resection achieved rapid resolution of obstructive uropathy. The patient was event-free at a 2-year follow-up.
Retroperitoneal cystic lymphangiomas is a rare benign tumor of the lymphatic system, characterized by proliferating lymphatic vessels, slowly growing cysts, and filling with chylous or serous material. It usually presents a diagnostic dilemma, as various types of cystic tumors share similar clinical manifestations. Occasionally, the cystic expansion is large enough to impose on surrounding structures, causing critical compression or obstruction of adjacent retroperitoneal organs. Generally, a total excision is the preferred treatment.
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W.-C. Tsai and W.-W. Chang contributed equally to this manuscript.
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Tsai, WC., Chang, WW. & Tsao, YT. Obstructive nephropathy presenting as seizures. Intensive Care Med 41, 920 (2015). https://doi.org/10.1007/s00134-014-3629-5
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DOI: https://doi.org/10.1007/s00134-014-3629-5