Zusammenfassung
Hintergrund und Fragestellung
Bahnbrechende Erkenntnisse bezüglich des humanen Mikrobioms und dessen Interaktion mit dem menschlichen Körper in Gesundheit und Krankheit werfen die Frage auf, ob und wie therapeutischer Einfluss auf dieses System genommen werden kann.
Material und Methoden
Überblick und Auswertung der für die Pädiatrie relevanten Fachpublikationen.
Ergebnisse
Der positive Nutzen von Probiotika auf den Verlauf oder die Prävention bestimmter Erkrankungen gilt als wahrscheinlich. Die Wirkung hängt jedoch von einer Vielzahl von Faktoren ab.
Schlussfolgerung
Probiotika stellen in vielen Fällen eine unbedenkliche, wenn auch nicht in allen Fällen erfolgversprechende Therapieoption dar. Fortschritte im Bereich der Mikrobiomforschung sowie ein besseres Verständnis der Interaktion einzelner Mikroorganismen und molekularer Wirkmechanismen werden die Qualität und die Indikation probiotischer Intervention zukünftig verbessern.
Abstract
Background and objective
Groundbreaking progress in the field of microbiome research, its role in diseases and its interactions with the human body to promote health have sparked an immense interest in the therapeutic possibilities of microbiome-modulating treatment.
Material and method
Review and analysis of the current scientific literature relevant for pediatrics.
Results
A benefit of probiotics in prevention or the course of several disease entities is likely. The impact is dependent on several influencing factors.
Conclusion
Probiotics constitute in many cases a harmless, even though not in all cases effective therapeutic option. Further improvements in the field of microbiome research and a better understanding of the interactions between different microorganisms and their molecular mechanism of action will yield improved application and increase the quality of probiotic interventions in the future.
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C.U. Meyer, J. Klopp, R.L. Knoll und S. Gehring geben an, dass kein Interessenkonflikt besteht.
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Meyer, C.U., Klopp, J., Knoll, R.L. et al. Beeinflussung des Mikrobioms durch Probiotika in der pädiatrischen Praxis. Monatsschr Kinderheilkd 167, 389–395 (2019). https://doi.org/10.1007/s00112-019-0690-8
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DOI: https://doi.org/10.1007/s00112-019-0690-8