Zusammenfassung
Mit den steigenden Überlebensraten nach pädiatrisch-onkologischen Therapien wächst die Zahl der Patienten, die Spätfolgen nach einer Tumortherapie aufweisen. Vor allem Schilddrüsenfunktions- und Schilddrüsenproliferationsstörungen sind häufige Folgen einer Behandlung von bösartigen Tumoren im Kindes- und Jugendalter. In erster Linie treten sie nach einer Bestrahlung auf die Schilddrüse oder auch auf Hypothalamus und Hypophyse auf. Die jetzt vorliegenden Leitlinien der Arbeitsgemeinschaft der Wissenschaftlichen Medizinischen Fachgesellschaften (AWMF) zur Nachsorge dieser Patienten empfehlen nach standardisierter Auswertung der gegenwärtig verfügbaren Literatur Vorgehensweisen, anhand deren die langfristige Nachsorge dieser Patienten erfolgen soll. Die vorliegende Übersicht fasst diese Vorgehensweisen für Spätfolgen einer Tumortherapie an Schilddrüse und Nebenschilddrüse zusammen.
Abstract
The increased survival rates after pediatric oncological therapy result in an increase in the number of patients showing late effects of tumor therapy. Thyroid function and proliferation disorders in particular are common sequelae of treatment of malignant tumors in childhood and adolescence. They predominantly occur after irradiation of the thyroid and also of the hypothalamus and pituitary glands. The current guidelines on endocrine late effects in these patients are endorsed by the working group of the Scientific Medical Specialist Societies (AWMF). Based on standardized evaluation of currently available literature this review article summarizes the approaches for late sequelae of tumor therapy on thyroid and parathyroid glands.
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Interessenkonflikt. G. Brabant, W. Dörffel, P. Vorwerk und H.-G. Dörr geben an, dass kein Interessenkonflikt besteht. Dieser Beitrag beinhaltet keine Studien an Menschen oder Tieren.
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Brabant, G., Dörffel, W., Vorwerk, P. et al. Schilddrüsen- und Nebenschilddrüsenerkrankungen. Monatsschr Kinderheilkd 163, 120–125 (2015). https://doi.org/10.1007/s00112-014-3174-x
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DOI: https://doi.org/10.1007/s00112-014-3174-x