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Anti-oxidative effects of superoxide dismutase 3 on inflammatory diseases

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Abstract

Free radicals and other oxidants are critical determinants of the cellular signaling pathways involved in the pathogenesis of several human diseases including inflammatory diseases. Numerous studies have demonstrated the protective effects of antioxidant enzymes during inflammation by elimination of free radicals. The superoxide dismutase (SOD), an antioxidant enzyme, plays an essential pathogenic role in the inflammatory diseases by not only catalyzing the conversion of the superoxide to hydrogen peroxide and oxygen but also affecting immune responses. There are three distinct isoforms of SOD, which distribute in different cellular compartments such as cytosolic SOD1, mitochondrial SOD2, and extracellular SOD3. Many studies have investigated the anti-oxidative effects of SOD3 in the inflammatory diseases. Herein, in this review, we focus on the current understanding of SOD3 as a therapeutic protein in inflammatory diseases such as skin, autoimmune, lung, and cardiovascular inflammatory diseases. Moreover, the mechanism(s) by which SOD3 modulates immune responses and signal initiation in the pathogenesis of the diseases will be further discussed.

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Acknowledgments

We would like to thank Chelsea Anita Kelland (Department of Internal Medicine, University of California at Davis, USA) and Minh Tan Nguyen (School of Dentistry, University of California at Los Angeles, USA) for their critical reading and useful discussions.

Funding

This work was supported by Nguyen Tat Thanh University (CTN-2019) and Ho Chi Minh City Open University (NHN-2019). The funding body played no role in the study design, data collection and analysis, decision to publish, or preparation of the manuscript.

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  1. Faculty of Biotechnology, Ho Chi Minh City Open University, 97 Vo Van Tan Street, District 3, Ho Chi Minh City, Vietnam

    Nguyen Hoai Nguyen

  2. Department of Biotechnology, Institute of Biotechnology and Food-technology, Industrial University of Ho Chi Minh City, Ho Chi Minh City, Vietnam

    Gia-Buu Tran

  3. NTT Hi-Tech Institute, Nguyen Tat Thanh University, Ho Chi Minh City, Vietnam

    Cuong Thach Nguyen

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Cuong T Nguyen searched the literatures and wrote the manuscript. Nguyen H Nguyen searched the literatures and participated in discussion. Gia-Buu Tran revised the manuscript.

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Nguyen, N.H., Tran, GB. & Nguyen, C.T. Anti-oxidative effects of superoxide dismutase 3 on inflammatory diseases. J Mol Med 98, 59–69 (2020). https://doi.org/10.1007/s00109-019-01845-2

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