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Design and synthesis of 6-alkyoxyl[1,2,4]triazolo[1,5-a]quinazoline derivatives with anticonvulsant activity

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Abstract

A series of novel 6-alkyoxyl[1,2,4]triazolo[1,5-a]quinazoline derivatives were synthesized in this study. The anticonvulsant activity of all the target compounds 4a–4s, characterized by IR, 1H-NMR and MS, were evaluated using Maximal electroshock test. The pharmacological results showed that some of the compounds displayed positive anticonvulsant activity. Among them, 6-(benzyloxy)-[1,2,4]triazolo[1,5-a]quinazoline (4a) was the most active compound with an ED50 value of 78.9 mg/kg and a PI value of 9.0.

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Acknowledgment

This study was supported by the National Natural Science Foundation of China (No. 30860340).

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Authors and Affiliations

  1. College of Pharmacy, Yanbian University, Yanji, Jili, 133002, People’s Republic of China

    Chun-Bo Zhang, Chuan-Wen Yang, **an-Qing Deng & Zhe-Shan Quan

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  1. Chun-Bo Zhang
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  2. Chuan-Wen Yang
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  3. **an-Qing Deng
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  4. Zhe-Shan Quan
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Correspondence to Zhe-Shan Quan.

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Zhang, CB., Yang, CW., Deng, XQ. et al. Design and synthesis of 6-alkyoxyl[1,2,4]triazolo[1,5-a]quinazoline derivatives with anticonvulsant activity. Med Chem Res 21, 3294–3300 (2012). https://doi.org/10.1007/s00044-011-9875-y

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