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Assessment of health state utilities for attention-deficit/hyperactivity disorder in children using parent proxy report

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Abstract

This study used standard gamble (SG) utility interviews to assess parent preferences for health states of childhood attention-deficit/hyperactivity disorder (ADHD). Health state utilities are needed to calculate quality-adjusted life years (QALYs), a critical outcome measure in cost-effectiveness studies of new treatments. Parents (n=43) of children diagnosed with ADHD completed SG utility interviews, rating their child’s current health and 11 hypothetical health states describing untreated ADHD and ADHD treated with a stimulant or non-stimulant. Parents completed questionnaires on their children’s symptoms and health-related quality of life (HRQL). Parents’ SG rating of their child’s current health state (mean of 0.74 on a utility scale ranging from 0 to 1) was significantly correlated with inattentive, hyperactive, and overall ADHD symptoms (r=0.37, 0.36, and 0.40 respectively; p < 0.05) and psychosocial HRQL domains. Hypothetical health state utilities ranged from 0.48 (severe untreated ADHD) to 0.88 (effective and tolerable non-stimulant treatment). Comparisons between health states found expected differences between untreated mild, moderate, and severe ADHD health states. When both treatments were effective and tolerable, parents preferred the non-stimulant health state over the stimulant health state (p < 0.03). Results suggest that parent SG interviews are a feasible and useful method for obtaining utility scores that can be used in cost-effectiveness models of ADHD treatment.

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Authors and Affiliations

  1. MEDTAP International, Inc., Center for Health Outcomes Research, 7101 Wisconsin Avenue, Suite 600, Bethesda, MD, USA, 20814

    Louis S. Matza, Anne M. Rentz, Sally Mannix & Dennis A. Revicki

  2. Eli Lilly & Company, Indianapolis, IN, USA

    Kristina Secnik

  3. Cincinnati Children’s Hospital, Cincinnati, OH, USA

    F. Randy Sallee & Donald Gilbert

Authors
  1. Louis S. Matza
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  2. Kristina Secnik
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  3. Anne M. Rentz
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  4. Sally Mannix
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  5. F. Randy Sallee
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  6. Donald Gilbert
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  7. Dennis A. Revicki
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Correspondence to Louis S. Matza.

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Matza, L.S., Secnik, K., Rentz, A.M. et al. Assessment of health state utilities for attention-deficit/hyperactivity disorder in children using parent proxy report. Qual Life Res 14, 735–747 (2005). https://doi.org/10.1007/PL00022070

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  • DOI: https://doi.org/10.1007/PL00022070

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