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Antimetastatic effect of integrin IIb/IIIa inhibitors on salivary adenoid cystic carcinoma

  • Clinical Observation
  • Published:
Chinese Journal of Cancer Research

Abstract

Objectives: To investigate the relation between metastatic potential of salivary adenoid cystic carcinoma (SACC) and tumor cell-platelet adhesion, and the antimetastatic effect of integrin IIb/IIIa inhibitor on SACC. Methods: Tumor cell-platelet adhesion of highly metastatic SACC-LM, non-highly metastatic SACC-83 and effect of aspirin, arginine-aspartate (RD), magnesium acetylsalicylate on adhesion were studiedin vitro. Antimetastafic effect of aspirin, RD, magnesium acetysalicylate on experimental metastasis of SACC was observedin vivo. Results: The tumor cell-platelet adhesion was stronger in SACC-LM than in SACC-83. Aspirin, RD and magnesium acetylsalicylate could inhibit the adhesion of SACC-LM at the concentration of 1, 5 and 25 µg/ml. RD can inhibit experimental metastasis of SACC. Conclusion: Metastasis of SACC is related to platelet-tumor cell adhesion, RD could inhibit metastasis of SACC.

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Authors and Affiliations

  1. Peking University School of Stomatology, 100081, Bei**g

    Li Feng-he, YU Guang-yan, Li Sheng-lin & Fu Jia

  2. Peking University School of Pharmacology, 100083, Bei**g

    Peng Shi-qi

Authors
  1. Li Feng-he
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  2. YU Guang-yan
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  3. Li Sheng-lin
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  4. Peng Shi-qi
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  5. Fu Jia
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Corresponding author

Correspondence to YU Guang-yan.

Additional information

Foundation item: The work was supported by the National Natural Science Foundation of China (No. 39270723).

Biography: LI Feng-he (1964-), attending physician, doctor of medicine, now works at Bethune International Peace Hospital, majors in stomatology, especially in maxillofacial surgery.

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Li, Fh., YU, Gy., Li, Sl. et al. Antimetastatic effect of integrin IIb/IIIa inhibitors on salivary adenoid cystic carcinoma. Chin J Cancer Res 13, 198–201 (2001). https://doi.org/10.1007/BF02983884

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  • DOI: https://doi.org/10.1007/BF02983884

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