Abstract
Our previous report demonstrated that certain flavonoid aglycones such as apigenin (flavone), quercetin, morin (flavonols), and biochanin A (isoflavone) showedin vivo antiinflammatory activityvia topical and oral routes of administration. As a continual study, the various flavonoid glycosides have been evaluated in mouse ear edema assay using archidonic acid or crotonoil as a inflammagen. Flavonoids were orally administered (2 mg/mouse) and ear edema inhibition was measured. Significant antiinflammatory activities were found especially in flavone and flavonol glycosides (15–19% inhibition) although the flavonoid derivatives tested showed less antiinflammatory activity than hydrocortisone or indomethacin. Chalcone and flavanone derivatives were not significantly active. And in general, flavonol glycosides of kaempferol-type were found to have a higher oral antiinflammatory activity than that of flavonol glycosides of quercetin-type in mice.
Similar content being viewed by others
Literature Cited
Arner, E. C., Rule, B. L., Rudnick, M. S. and Galbraith, W., Arachidonic acid induced ear edema: Correlation of swelling with production of lipoxygenase (LO) products.Agents and Actions, 16, 600–601 (1985).
Chamsuksai, P., Choi, J. S. and Woo, W. S., 3′,4′,7-Trihydroxyflavone inAlbizzia julibrissin.Arch. Pharm. Res., 4, 129–131 (1981).
Chi, H. J., Shin, K. H. and Kang, S. S., Systematic collection and evaluation of genetic resources of medicinal plants. pp. 141 (1989).
Do, J. C., Yu, Y. J., Jung, K. Y. and Son, K. H., Flavonoids from the leaves ofPolygala japonica.Kor. J. Pharmacogn., 23, 9–13 (1992).
Ferrandiz, M. L., Ramachandran Nair, A. G. and Alcaraz, M. J., Inhibition of sheep platelet arachidonate metabolism by flavonoids from Spanish and Indian medicinal herbs.Pharmazie, 45, 206–208 (1990).
Gabor, M., Anti-inflammatory and antiallergy properties of flavonoids, In Cobyet al. (eds.),Plant Flavonoid in Biology and Medicine; Biochemical, Pharmacological and Structure-Activity Relationships. Alan R. Liss, New York, 1986, pp. 471.
Havsteen, B., Flavonoids, a class of natural products of high pharmacological potency.Biochem. Pharmacol., 32, 1141–1148 (1983).
Jung, K. Y., Son, K. H. and Do, J. C., Summitted for publication toKor. J. Pharmacogn. (1992).
Kang, S. S., Lee, Y. S. and Lee, E. B.: Saponins and flavonoid glycosides from Yellow Sweetclover.Arch. Pharm. Res., 11, 197–202 (1988).
Kang, S. S., Kim, J. S., Kwak, W.-J. and Kim, K.-H., Flavonoids from the leaves ofGinkogo biloba.Kor. J. Pharmacogn., 21, 111–120 (1990).
Kang, S. S., Kang, Y. J. and Lee, M. W., Flavonodis fromEpimedium koreanum.J. Nat. Prod., 54, 542–546 (1991).
Kim, H. K., Namgoong, S. Y. and Kim, H. P., Anti-inflammatory activity of flavonoids: Mice ear edema inhibition.Arch. Pharm. Res., 18–24 (1992).
Lewis, D. A., Flavonoids, InLewis, D. A. (eds),Anti-inflammatory Drugs from Plant and Marine Sources. Berkhauser-Verlag, Basel, 1989, pp. 137.
Middleton, E. and Kandaswami, C., Effects of flavonoids on immune and inflammatory cell functions.Biochem. Pharmacol., 43, 1167–1179 (1992).
Tonneli, G., Thiabault, L. and Ringler, I., A bioassay for the concommitant assessment of the antiphlogistic and thymolytic activities of topically applied corticoids.Endocrinol., 77, 625–634 (1965).
Woo, W. S., Kang, S. S., Shim, S. H., Wagner, H., Chari, V. M., Seligmann, O. and Obermeier, C., The structure of spinosine (2″-O-glucosylswertisin) fromZizyphus vulgaris var.spinosus.Phytochem., 18, 353–355 (1979).
Woo, W. S., Kang, S. S., Wagner, H., Seligmann, O. and Chari, V. M., Acetylated flavone-C-glycosides from the seeds ofZizyphus jujuba.Phytochem., 19, 2791–2793 (1980).
Welton, A. F., Hurley, J. and Will, P., Flavonoids and arachidonic acid metabolism, In Cobyet al. (eds),Plant Flavonoids in Biology and Medicine II: Biochemical, Cellular, and Medicinal Properties. Alan R. Liss, New York, 1988, pp. 301.
Yasukawa, K., Takido, M., Takeuchi, M. and Nakagawa, S., Effect of chemical constituents from plants on 12-O-tetradecanoylphorbol-13-acetate-induced inflammation in mice.Chem. Pharm. Bull., 37, 1071–1073 (1989).
Author information
Authors and Affiliations
Rights and permissions
About this article
Cite this article
Lee, S.J., Son, K.H., Chang, H.W. et al. Antiinflammatory activity of naturally occurring flavone and flavonol glycosides. Arch. Pharm. Res. 16, 25–28 (1993). https://doi.org/10.1007/BF02974123
Received:
Issue Date:
DOI: https://doi.org/10.1007/BF02974123