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Effect of cardiopulmonary bypass on the specific immunity of the host

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Summary

T cell subsets and immunoglobulin (Ig) were observed sequentially with the OKT monoclonal antibodies rosette test and the rate scattering turbidimetry in 13 patients who underwent open heart surgery under cardiopulmonary bypass (CPB) for rheumatic heart diseases (RHD) and congenital heart diseases (CHD), before and after operation. Compared with preoperative values, in the early period after CPB, T helper cells, T helper cells to T suppressor cells ratio and IgG decreased significantly; whereas T suppressor cells increased, in RHD and CHD. The T cell subsets returned to the preoperative levels two weeks after CPB in RHD and CHD. The IgG came back to the preoperative levels two weeks after CPB in RHD and only one week after CPB in CHD.

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Authors and Affiliations

  1. Institute of cardiovascular disease, Tongji Medical University, Wuhan

    LÜ Qi, Lan Hong-jun, Cai Jun-jian & Sun Zhong-quan

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  1. LÜ Qi
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  2. Lan Hong-jun
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  3. Cai Jun-jian
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  4. Sun Zhong-quan
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Qi, L., Hong-jun, L., Jun-jian, C. et al. Effect of cardiopulmonary bypass on the specific immunity of the host. Journal of Tongji Medical University 13, 231–233 (1993). https://doi.org/10.1007/BF02888016

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  • DOI: https://doi.org/10.1007/BF02888016

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