Abstract
Seventy-four cases of colonic cancer were studied by immunohistochemistry using anti-Chromogranin A, gastrin, somatostatin, serotonin, glucogon and human chorionic gonadotropin (HCG) to observe the neuroendocrine cell in clonic cancer. It was found that 27 of 74 colonic carcinoma showed variable extent of CgA staining (36.5%). Glucagon and HCG was differently the most frequent in hormone antigens in colonic cancer and in metastatic lymph nodes. The endocrine positive colonic carcinomas are more frequent in poorly-differentiated than in well-differentiated (P<0.05). It suggests that there were different NE cells producing different hormones in colonic cancer. Different hormones may act on different types of colonic cancer.
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Hayashi H, Ooi A, Nakanishi I. Biological And Clinicopathological Significance of Endocrine Differentiation of Gastric adenocarcinoma Evaluated by Double Immunohistochemical Labeling for Chromogranin A And Bromodeoxyuridine. Jpn J Clin Oncol 1990; 20(4):339.
Stamm B, Sarmaslani P. Coincidence of Fundic Gladular Hyperplasia And Hormonal Content of Endocrine Cells in Gastric Cancer. Histopathology 1989; 63(5):354.
Smith JP, Solomon TE. Effects of Gastrin, Proglumide And Somatostatin on Growth of Human Colon Cancer. Gastroenterology 1988; 95(8):1541.
Ito H, Yokozaki H, Hata J, Mandai K, et al. Glicentincontaining Cells in Intestinal Metaplasia, Adenoma And Carcinoma of the Stomach. Virchows arch pathol anat 1984; 404(1):17.
Cuttitta F, Carney DN, Mulshine J. Bombesinlike Peptides Can function As Autocrine Growth Factors in Human Small Cell Lung Cancer. Nature 1985; 316. (4):823.
Camp, E, Palacin A, Benasco C, et al. Human chorionic Gonadopiopin in Colorectal Carcinoma. Cancer 1987; 59(9):1611.
Laburthe M, Roussertt M, Chevalier G, et al. Vasoactive Intestinal Polypeptide Control of Cyclic 3′: 5′-Monophosphatase Levels in Seven Human Colorectal Adenocarcinoma Cell Lines in Cuture. Cancer Res 40(12):2529.
Dawson IMP. Diffuse endocrine And Neuroendocrine Cell Tumours in Anthony PP, Macsween RNM, eds. Recent Advances Histopathology. Edinburgh: Churchill Livingstone. 1993:111–128.
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Jiyao, Y., Yandong, L. & Jialing, W. An immunohistochemical study of neuroen-docrine cells in colonic carcinoma. Chinese Journal of Cancer Research 8, 105–108 (1996). https://doi.org/10.1007/BF02675047
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DOI: https://doi.org/10.1007/BF02675047