Abstract
Amphetamine-induced place conditioning was evaluated in mice using a newly designed apparatus. It was demonstrated that this apparatus provides a neutral set of cues devoid of rewarding or aversive properties and can reveal place preference or aversion after pairings with drugs (amphetamine and morphine for preference and naloxone for aversion) known to produce such effects. Moreover, repeated pairings of environmental cues with either 2 or 3 mg/kgd-amphetamine resulted in significant conditioned place preference on a drug free test, whilst repeated pairings with a lower dose of the drug (1 mg/kg) resulted in significant conditioned place aversion. Finally, a small number of mice showed opposite responses in comparison with group means at low as well as at high doses of amphetamine. These results suggest that amphetamine may promote conditioned place preference or avoidance depending on dosage and individual susceptibility.
References
Cabib S (1993) Strain-dependent behavioural sensitization to amphetamine: role of environmental factors. Behav Pharmacol 4:367–374
Carey RJ (1978) A comparison of the food intake suppression produced by giving amphetamine as an aversion treatment versus an anorexic treatment. Psychopharmacology 56:45–48
Carr GD, White NM (1986) Anatomical dissociation of amphetamine's rewarding and aversive effects: an intracranial micro-injection study. Psychopharmacology 89:340–346
Carr GD, Fibiger HC, Phillips AG (1989) Conditioned place preference as a measurer of drug reward. In: Leibman JM, Cooper SJ (eds) Oxford review in psychopharmacology. Oxford University Press, Oxford
Gora-Maslak G, McClearn GE, Crabbe JC, Phillips TJ, Belknap JK, Plomin R (1991) Use of recombinant inbred strains to identify quantitative trait loci in psychopharmacology. Psychopharmacology 104:413–424
Goudie AJ (1929) Aversive stimulus properties of drugs. Neuropharmacology 13:971–979
Haertzen CA, Kocher TR, Mijasato K (1983) Reinforcement from the first drug experience can predict later drug habits and/or addiction: results with cofee, cigarettes, alcohol, barbiturates, major and minor tranquilliser, stimulants, marijuana, hallucinogens, heroin, opiates and cocaine. Drug Alcohol Depend 11:147–165
Le Magnen J (1969) Peripheral and systemic actions of food in caloric regulation of intake. Ann NY Acad Sci Vol 157:1126–1157
Lett BT (1988) Enhancement of conditioned preference for a place paired with amphetamine produced by blocking the association between place and amphetamine-induced sickness. Psychopharmacology 95:390–394
Mello NK (1983) A behavioral analysis of the reinforcing properties of alchool and other drugs in man. In: Kissin B, Begleiter H (eds) The pathogenesis of alcoholism, biological factors, vol. 7. Plenum Press, New York, pp 133–198
Meyer RE, Mirin JM (1979) The heroin stimulus implications for a theory of addiction. Plenum Press, New York
Oliverio A, Cabib S, Puglisi-Allegra S (1992) Nonhuman behavioral models in genetics of disturbed behavior. J Psychiatr Res 26[4]:367–382
Piazza P-V, Deminiere JM, Le Moal M, Simon H (1989) Factors that predict individual vulnerability to amphetamine self-administration. Science 245:1511–1513
Plomin R (1990) The role of inheritance in behavior. Science 183:183–188
Reicher MA, Holman EW (1977) Location preference and flavour aversion reinforced by amphetamine in rats. Anim Learn Behav 5:543–546
Resnick RB, Kestenbaum RS, Schwartz LK (1977) Acute systemic effects of cocaine in man: a controlled study by intranasal and intravenous routes. Science 195:696–698
Schechter MD, Calcagnetti DJ (1993) Trends in place preference conditioning with a cross-indexed bibliography; 1957–1991. Neurosci Biobehav Rev 17:21–41
Stolerman IP, D'Mello GD (1978) Amphetamine-induced hypodipsia and its implications for conditioned taste aversion in rats. Pharmacol Biochem Behav 8:333–338
Tabakoff B, Hoffman PL (1988) A neurobiological theory of alcoholism. In: Chandron CD, Wilkinson DA (eds) Theories of alcoholism. Addiction Research Foundation, Toronto, pp 29–72
Wall AM, Hinson RE, Schmidt E, Johoston C, Streather A (1990) Place conditioning withd-amphetamine: the effect of the CSUCS interval and evidence of a place avoidance. Anim Learn Behav 18 [4]:393–400
White NM, Packard MG, Hiroi N (1991) Place conditioning with dopamine D1 and D2 agonists injected peripherally or into the nucleus accumbens. Psychopharmacology 103:271–276
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Cabib, S., Puglisi-Allegra, S., Genua, C. et al. Dose-dependent aversive and rewarding effects of amphetamine as revealed by a new place conditioning apparatus. Psychopharmacology 125, 92–96 (1996). https://doi.org/10.1007/BF02247398
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DOI: https://doi.org/10.1007/BF02247398