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A case study of the cognitive and behavioral deficits of temporal lobe damage in herpes simplex encephalitis

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Abstract

Herpes simplex viral encephalitis is a fairly common nonepidemic encephalitis which produces severe neurological sequelae in survivors. Most viral infections of the central nervous system produce diffuse damage, but the herpes simplex virus demonstrates a predilection for localization in the temporal and orbitofrontal regions of the brain. This case study illustrates the highly significant language difficulties, marked memory deficits, and propensity for physical aggression following temporal lobe damage brought about by herpes encephalitis, and presents the usefulness of a new diagnostic measure in delineating such a variable cognitive pattern.

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References

  • Arlazoroff, A., Carpel, C. L., Zonis, H., Goldenberg, E., & Zekler, E. (1984). Incomplete Kluver-Bucy syndrome and fluent aphasia.Brain and Language, 23, 300–306.

    Google Scholar 

  • Boucher, J., & Warrington, E. K. (1976). Memory deficits in early infantile autism: Some similarities to the amnesia syndrome.British Journal of Psychology, 67, 73–87.

    Google Scholar 

  • Corkin, S., Cohen, N. J., Sullivan, E. V., Clegg, R. A., & Rosen, T. J. (1985). Analyses of global memory impairments of different etiologies.Annals of New York Academy of Sciences, 444, 10–40.

    Google Scholar 

  • DeLong, G. R., Bean, S. C., & Brown, F. R., III, (1981). Acquired reversible autistic syndrome in acute encephalopathic illness in children.Archives of Neurology, 38, 191–194.

    Google Scholar 

  • Drachman, D. A., & Adams, R. D. (1962). Herpes simplex and acute inclusion-body encephalitis.Archives of Neurology, 7, 45.

    Google Scholar 

  • Gillberg, C. (1986). Brief report: Onset at age 14 of a typical autistic syndrome. A case report of a girl with herpes simplex encephalitis.Journal of Autism and Developmental Disorders, 16, 369–375.

    Google Scholar 

  • Kluver, H., & Bucy, P. C. (1938). An analysis of certain effects of bilateral temporal lobectomy in the rhesus monkey, with special reference to “psychic blindness”.Journal of Psychology, 5, 33–54.

    Google Scholar 

  • Mattis, S., Kovner, R., & Goldmeier, E. (1978). Different patterns of mnemonic deficits in two organic amnestic syndromes.Brain and Language, 6, 179–191.

    Google Scholar 

  • McFarland, D. J., & Hotchin, J. (1983). Host genetics and the behavioral sequelae to herpes encephalitis in mice.Physiology and Behavior, 30, 881–884.

    Google Scholar 

  • New, P. F. J., & Davis, K. R. (1980). The role of CT scanning in diagnosis of infections of the central nervous system. In J. S. Remington & M. N. Swartz (Eds.),Current clinical topics in infectious disease (pp. 1–33). New York: McGraw-Hill.

    Google Scholar 

  • Olson, L. C., Buescher, E. L., Artenstein, M. S., & Parkman, P. D. (1967). Herpesvirus infections of the human central nervous system.New England Journal of Medicine, 277, 1271–1277.

    Google Scholar 

  • Roach, E. S., & Abramson, J. (1985). Delayed recovery from herpes (letter).Pediatric Infectious Disease, 4, 703.

    Google Scholar 

  • Rogers, C. D., & Peters, P. (1979). Reading recovery following herpes encephalitis.Journal of Learning Disabilities, 12, 572–575.

    Google Scholar 

  • Starr, A., & Phillips, L. (1970). Verbal and motor memory in the amnestic syndrome.Neuropsychologia, 8, 75–88.

    Google Scholar 

  • Stubbs, E. G., Ash, E., & Williams, C. P. S. (1984). Autism and congenital cytomegalovirus.Journal of Autism and Developmental Disorders, 14, 183–189.

    Google Scholar 

  • Sugimoto, T., Woo, M., Okazaki, H., Hishida, N., Hara, T., Yasuhara, A., Kasahara, M., & Kobayashi, Y. (1985). Computed tomography in young children with herpes simplex virus encephalitis.Pediatric Radiology, 15, 372–376.

    Google Scholar 

  • Thorndike, R. L., Hagen, E. P., & Sattier, J. M. (1986).Stanford-Binet Intelligence Scale (4th ed.). Chicago: Riverside.

    Google Scholar 

  • Tizard, B. (1962). The personality of epileptics: A discussion of the evidence.Psychological Bulletin, 59, 196–210.

    Google Scholar 

Download references

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Authors and Affiliations

  1. Department of Pediatrics, Medical University of South Carolina, 171 Ashley Avenue, 29425, Charleston, South Carolina

    Margaret K. Greer, Meredith Lyons-Crews & Frank R. Brown III

  2. Department of Pediatrics, University of South Carolina School of Medicine, Columbia

    Lawrence B. Mauldin

Authors
  1. Margaret K. Greer
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  2. Meredith Lyons-Crews
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  3. Lawrence B. Mauldin
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  4. Frank R. Brown III
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Greer, M.K., Lyons-Crews, M., Mauldin, L.B. et al. A case study of the cognitive and behavioral deficits of temporal lobe damage in herpes simplex encephalitis. J Autism Dev Disord 19, 317–326 (1989). https://doi.org/10.1007/BF02211849

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  • DOI: https://doi.org/10.1007/BF02211849

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