Abstract
Histological and immunohistochemical studies of a granular cell tumor involving the lower lid are described. Histological examination showed it to have typical features of a granular cell tumor. Nervous-system-specific protein (S-100 protein) was detected in both the nuclei and cytoplasm of granular cells using the peroxidase-anti-peroxidase method. This result further supports the concept of the neurogenic origin of granular cell tumors.
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References
Abrikossoff A (1926) Über Myome, ausgehend von der quergestreiften willkiürlichen Muskulatur. Virchows Arch Pathol Anat Physiol 260: 215–233
Berman JJ, Rice JM, Strandberg J (1978) Granular cell variants in a rat schwannoma: evidence of neurogenic origin of granular cell tumor (myoblastoma). Vet Pathol 15: 725–731
Cocchia D, Michetti F, Donato R (1981) Immunochemical and immunocytochemical localization of S-100 antigen in normal human skin. Nature 294: 85–87
Cochran AJ, Wen D-R, Herschman HR, Gaynor RB (1982) Detection of S-100 protein as an aid to the identification of melanocytic tumors. Int J Cancer 30: 295–297
Cochran AJ, Holland GN, Wen D-R, Herschman HR, Lee WR, Foos RY, Straatsma BR (1983) Detection of cytoplasmic S-100 protein in primary and metastatic intraocular melanomas. Invest Ophthalmol Vis Sci 24: 1153–1155
Cristini G (1946) Mioblastoma della Palpebra. Rass Ital Ottal 15: 207–223
Feyrter F (1935) Über eine eigenartige Geschwulstform des Nervengewebes im menschlichen Verdauungsschlauch. IV. Teil der Beiträge zur Geschwulstlehre (nach Untersuchungen am menschlichen Magen und Darm). Virchows Arch Pathol Anat Physiol 295: 480–501
Fisher ER, Wechsler H (1962) Granular cell myoblastoma — a misnomer. Electron microscopic and histochemical evidence concerning its Schwann cell derivation and nature (granular cell schwannoma). Cancer 15: 936–954
Friedman Z, Eden E, Neumann E (1973) Granular cell myoblastoma of the eyelid margin. Br J Ophthalmol 57: 757–760
Garancis JC, Komorowski RA, Kuzma JF (1970) Granular cell myoblastoma. Cancer 25: 542–550
Gaynor R, Irie R, Morton D, Herschman HR (1980) S-100 protein is present in cultured human malignant melanomas. Nature 286: 400–401
Haglid K, Carlsson C-A, Stavrou D (1973) An immunological study of human brain tumors concerning the brain specific proteins S-100 and 14.3.2. Acta Neuropath (Berl) 24: 187–196
Hansson H-A, Persson L, Rönnbäck L, Haglid KG (1976) Immuno-electron microscopic study of the distribution of the S-100 protein in brain glial cells. Cytobios 15: 45–48
Kretsinger RH (1980) Structure and evolution of calcium-modulated proteins. CRC Crit Rev Biochem 8: 119–174
Moore BW (1965) A soluble protein characteristic of the nervous system. Biochem Biophys Res Commun 19: 739–744
Nakazato Y, Ishizeki J, Takahashi K, Yamaguchi H (1982) Immunohistochemical localization of S-100 protein in granular cell myoblastoma. Cancer 49: 1624–1628
Pearse AGE (1950) The histogenesis of granular-cell myoblastoma (granular-cell perineural fibroblastoma). J Pathol Bacteriol 62: 351–362
Rubenzik R, Tenzel RR (1976) Granular cell myoblastoma of the lid: Case report. Ann Ophthalmol 8: 421–422
Shousha S, Lyssiotis T (1979) Granular cell myoblastoma: Positive staining for carcinoembryonic antigen. J Clin Pathol 32: 219–224
Stefansson K, Wollmann RL (1982) S-100 protein in granular cell tumors (granular cell myoblastomas). Cancer 49: 1834–1838
Stefansson K, Wollmann RL, Moore BW (1982a) Distribution of S-100 protein outside the central nervous system. Brain Research 234: 309–317
Stefansson K, Wollmann RL, Moore BW, Arnason BGW (1982b) S-100 protein in human chondrocytes. Nature 295: 63–64
Sternberger LA, Hardy PH, Cuculis JJ, Meyer HG (1970) The unlabeled antibody enzyme method of immunohistochemistry. Preparation and properties of soluble antigen-antibody complex (horseradish peroxidase-antihorseradish peroxidase) and its use in identification of spirochetes. J Histochem Cytochem 18: 315–333
Takahashi K, Yamaguchi H, Ishizeki J, Nakajima T, Nakazato Y (1981) Immunohistochemical and immunoelectron microscopic localization of S-100 protein in the interdigitating reticulum cells of the human lymph node. Virchows Arch (Cell Pathol) 37: 125–135
Timm G, Timmel H (1966) Zum Myoblastenmyom am Auge. Klin Monatsbl Augenheilkd 148: 665–671
Yamaguchi H (1980) Studies on the immunohistochemical localization of S-100 and glial fibrillary acidic proteins in the rat nervous system and in human brain tumors. No To Shinkei 32: 1055–1064
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Ishibashi, T., Yoshitomi, T., Ohnishi, Y. et al. Granular cell tumor of the lower lid: histological and immunohistochemical studies. Graefe's Arch Clin Exp Ophthalmol 222, 75–78 (1984). https://doi.org/10.1007/BF02150635
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DOI: https://doi.org/10.1007/BF02150635