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Enhanced anti-inflammatory effect and reduced immunogenicity of bovine liver superoxide dismutase by conjugation with homologous albumin

  • Immunosuppression and Inflammation
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Abstract

Bovine liver superoxide dismutase (SOD) can be crosslinked to albumin to form soluble conjugates with up to 70% retention of original enzyme activity. These conjugates have markedly prolonged plasma half-times of enzymatic activity (15 h) compared to native SOD (6 min). The conjugates have potent anti-inflammatory effects in vivo and reduced immunogenicity and antigenicity compared to native SOD. These conjugates provide new possibilities for the study of inflammation and its treatment.

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Authors and Affiliations

  1. Rheumatic Disease Unit, Department of Medicine, University of Alberta, 9-112 Clinical Sciences Building, T6G 2G3, Edmonton, Alberta, Canada

    K. Wong, L. G. Cleland & M. J. Poznansky

  2. Department of Physiology, University of Alberta, 9-112 Clinical Sciences Building, T6G 2G3, Edmonton, Alberta, Canada

    K. Wong, L. G. Cleland & M. J. Poznansky

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  1. K. Wong
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  2. L. G. Cleland
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  3. M. J. Poznansky
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Wong, K., Cleland, L.G. & Poznansky, M.J. Enhanced anti-inflammatory effect and reduced immunogenicity of bovine liver superoxide dismutase by conjugation with homologous albumin. Agents and Actions 10, 231–239 (1980). https://doi.org/10.1007/BF02025941

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  • DOI: https://doi.org/10.1007/BF02025941

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