Abstract
Chronic epicutaneous application of phorbol-12-myristate-13-acetate (PMA) on the right flank of C 57 BL/6 mice induces an inflammatory reaction and a selective increase in skin histamine level at the site of treatment. Tissue histamine levels were not increased at other sites such as controlateral skin, stomach rumen and skeletal muscle, and were decreased in stomach fundus and dorsal skin. These results are in agreement with the hypothesis that mast cells play a significant role in cutaneous inflammation induced by PMA.
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References
R. K. Boutwell,The function and mechanism of promoters of carcinogenesis. CRC Crit. Rev. Toxicol.2, 419–426 (1974).
S. J. Galli, B. K. Wershil, H. Yano, N. Arizono, J. R. Gordon and T. Murakami,Analysis of the roles of phenotypically distinct mast cell populations in non immunological responses. InMast cell and basophil differentiation and fucntion in health and disease (Ed. S. J. Galli and F. Austen) pp. 255–273, Raven Press, Ltd., New York, 1989.
J. R. Cordon and S. J. Galli,Phorbol 12-Myristate 13-Acetate-induced development of functionally active mast cells in W/W v but not S1/S1 d genetically mast cell-deficient mice. Blood75, 1637–1645 (1990).
J. F. Riley and G. B. West,The presence of histamine in tissue mast cells. J. Physiol., London,120, 528–530 (1953).
J. F. Riley and G. B. West,The occurrence of histamine in mast cells. InHistamine and antihistaminics; Part 1: Histamine, its chemistry, metabolism and physiological and pharmacological actions, Vol. 28/1 (Ed. Rocha E. Silva) pp. 116–135, Springer Verlag, Berlin
L. Galoppin, F. Raynaud, C. Ponvert, A. Fray, P. Scheinmann, G. Lespinats, P. Canu and C. Burtin,Tissue histamine levels and mast cell numbers in tumor-bearing mice. Agents Actions14, 494–496 (1984).
C. Ponvert, L. Galoppin, P. Scheinmann, P. Canu and C. Burtin,Tissue histamine levels in male and female mast cell-deficient mice (W/W v)and in their littermates (W v/+,W/+ and +/+). Agents Actions17, 1–4 (1985).
C. Burtin, P. Scheinmann, J. C. Salomon, G. Lespinats, C. Frayssinet, B. Lebel and P. Canu,Increased tissue histamine in tumor-bearing mice and rats. Br. J. Cancer43, 684–688 (1981).
P. A. Shore, A. A. Burkhalter and U. H. Cohn,A method for the fluorometric assay of histamine in tissues. J. Pharmac. exp. Ther.127, 182–186 (1959).
R. P. Siraganian and M. J. Brodski,Automated histamine analysis for in vitro allergy testing. J. Allergy Clin. Immunol.57, 525–540 (1976).
B. Lebel,A high sampling rate automated continuous-flow fluorometric technique for the analysis of nanogram levels of histamine in biological samples. Analyt. Biochem.133, 16–29 (1983).
B. K. Wershil, T. Murakami and S. J. Galli,Mast cell-dependent amplification of an immunologically non specific inflammatory response. Mast cells are required for the full expression of cutaneous acute inflammation induced by Phorbol 12-Myristate 13-Acetate. J. Immunol.140, 2356–2360 (1988).
S. D. Wright and B. C. Meyer,Phorbol esters cause sequential activation and deactivation of complement receptors on polymorphonuclear leukocytes. J. Immunol.136, 1759–1764 (1986).
M. Baggiolini and B. Dewald,Exocytosis by neutrophils. Contemp. Top. Immunobiol.14, 221–246 (1984)
I. M. Goldstein,Neutrophil degranulation. Contemp. Top. Immunobiol.14, 189–220 (1984).
S. J. Klebanoff,Phagocytic cells: products of oxygen metabolism. InInflammation: basic principles and clinical correlates (Ed. I. M. Goldstein and R. Snyderman) pp. 391–444, Raven Press, Ltd., New York 1988.
E. A. Jaffe,Endothelial cells. InInflammation: basic principles and clinical correlates (Ed. I. M. Goldstein and R. Snyderman) pp. 559–576, Raven Press, Ltd., New York, 1988.
H. F. Dvorak, S. J. Galli and A. M. Dvorak,Cellular and vascular manifestations of cell-mediated immunity. Human Pathol.17, 122–137 (1986).
P. W. Askenase, S. Bursztajn, M. D. Gershon and R. K. Gershon,T cell-dependent mast cell degranulation and release of serotonin in murine delayed hypersensitivity. J. Exp. Med.152, 1358–1374 (1980).
H. van Loveren, R. Meade and P. W. Askenase,An early component of delayed-type hypersensitivity mediated by T cells and mast cells. J. Exp. Med.157, 1604–1617.
J. Garssen, F. P. Nijkamp, S. S. Wagenaar, A. Awart and P. W. Askenase,Regulation of delayed-type hypersensitivity-like responses in the mouse lung, determined with histological procedures: serotonin, T cell supressor-inducer factor, and high antigen dose tolerance regulate the magnitude of T cell-dependent inflammatory reactions. Immunology68, 51–58 (1989).
Y. A. Mekori and Z. Zeidan,Mast cells in non-allergic immune responses in vivo. Israel J. Med. Sci.26, 337–341 (1990).
H. Takizawa, K. Ohta, K. Hirai, Y. Misaki, T. Horiuchi, N. Kobayashi, J. Shiga and T. Miyamoto,Mast cells are important in the development of hypersensitivity pneumonitis. A study with mast cell-deficient mice. J. Immunol.143, 1982–1988 (1989).
R. Qureshi and B. A. Jakschik,The role of mast cells in thioglycollate-induced inflammation. J. Immunol.141, 2090–2096 (1988).
M. Shimada, Y. Kitamura, M. Yokoyama, Y. Miyano, K. Maeyama, A. Yamatodani, Y. Takahashi and M. Tatsuta,Spontaneous stomach ulcer in genetically mast cell-depleted W/W v mice. Nature283, 662–664 (1980).
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Ponvert, C., Burtin, C., Canu, P. et al. Modifications in tissue histamine levels in mice treated with chronic epicutaneous application of phorbol-12-myristate-13-acetate. Agents and Actions 35, 159–162 (1992). https://doi.org/10.1007/BF01997494
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DOI: https://doi.org/10.1007/BF01997494