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Mannitol treatment of cerebral edema in rats with galactosamine-induced severe hepatitis

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Summary

Severe hepatitis is induced with D-galactosamine hydrochloride in rats. Animals develop brain edema which was treated with mannitol. 1 h after the last mannitol infusion brain water content decreased, but it was not decreased 6 h after treatment. The therapy reduced lethality (p<0.025). The rigorous brain edema therapy impoved the prognosis of fulminant hepatic failure in the rat.

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Authors and Affiliations

  1. Department of Medicine, Kantonsspital, University of Basel, CH-4031, Basel, Switzerland

    W. Zimmerli, Ch. Grubinger, H. Thölen, M. Oberholzer & L. Bianchi

  2. Institute of Pathology, Kantonsspital, University of Basel, CH-4031, Basel, Switzerland

    W. Zimmerli, Ch. Grubinger, H. Thölen, M. Oberholzer & L. Bianchi

  3. Divisions des Maladies infectieuses, Hôpital cantonal, CH-1211, Genève, Switzerland

    W. Zimmerli

Authors
  1. W. Zimmerli
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  2. Ch. Grubinger
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  3. H. Thölen
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  4. M. Oberholzer
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  5. L. Bianchi
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Additional information

Acknowledgments. We thank Mr Zarko Rajacic for expert technical help and Professor Werner Stauffacher for discussion of the manuscript and critical comments.

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Zimmerli, W., Grubinger, C., Thölen, H. et al. Mannitol treatment of cerebral edema in rats with galactosamine-induced severe hepatitis. Experientia 37, 1323–1325 (1981). https://doi.org/10.1007/BF01948387

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