Summary
Antibodies to somatostatin, a recently isolated hypothalamic peptide inhibiting growth hormone release, were used in immunohistochemical studies on the gastrointestinal tract. Somatostatin containing cells in the stomach, and somatostatin-containing nerves in the small and large intestine, could be demonstrated. These findings give evidence of a new type of nerve in the gut.
This is a preview of subscription content, log in via an institution to check access.
Similar content being viewed by others
Literatur
A. Kuntz,The Autonomic Nervous System (Lea-Febiger, Philadelphia 1953).
K. A. Norberg andB. Hamberger, Acta physiol. scand.63, Suppl. 238, 1 (1964).
D. Jacobowitz, J. Pharmac. exp. Ther.149, 358 (1965).
G. Burnstock, Pharmac. Rev.24, 509 (1972).
G. Nilsson, L. I. Larsson, R. Håkansson, E. Brodin, F. Sundler andB. Pernow, Histochemie, in press.
U. S. von Euler andJ. H. Gaddum, J. Physiol., Lond.72, 74 (1931).
B. Pernow, Acta physiol. scand.29, Suppl. 105, 1 (1953).
P. Brazeau, W. Vale, R. Burgus, N. Ling, M. Butcher, J. Rivier andR. Guillemin, Science179, 77 (1973).
M. P. Dubois, J. Barry andJ. Leonardelli, C. r. Acad. Sci., Paris279, 1899 (1974).
T. Hökfelt, S. Efendic, O. Johansson, R. Luft andA. Arimura, Brain Res.80, 165 (1974).
G. Pelletier, F. Labrie, A. Arimura andA. V. Schally, Am. J. Anat.140, 445 (1974).
R. Luft, S. Efendic, T. Hökfelt, O. Johansson andA. Arimura, Med. Biol.52, 428 (1974).
A. Arimura, H. Sato, A. Dupont, N. Nishi andA. V. Schally, Science, in press.
A. Arimura, H. Sato, D. H. Coy andA. V. Schally, Proc. Soc. exp. Biol. Med., in press.
D. C. Pease, Anat. Rec.142, 342 (1962).
T. Hökfelt, K. Fuxe, M. Goldstein andT. J. Joh, Histochemie33, 231 (1973).
B. K. Hartman, D. Zide andS. Udenfriend, Natn. Acad. Sci., USA69, 2722 (1972).
T. Hökfelt, S. Efendic, C. Hellerström, O. Johansson, R. Luft andA. Arimura, Acta Endocrinol, in press.
The immunohistochemical analysis of the distribution of Substance P in the gastrointestinal tract is carried out by the authors cited under ref.5. A full account of this work on different parts of this organ system in different species will be published elsewhere by these authors.
G. Nilsson, B. Pernow, G. H. Fisher andK. Folkers, Acta physiol. scand., in press.
K. G. M. Alberti, S. E. Christensen, J. Iversen, N. J. Sayer-Hansen, N. J. Christensen, A. Prange-hansen, K. Lundbaeck andH. Ørskov, Lancet2, 1299 (1973).
F. P. Alford, S. R. Bloom, J. D. N. Nabarro, R. Hall, G. M. Besser, D. H. Coy, A. J. Kastin andA. V. Schally Lancet2, 974 (1974).
S. Efendic andR. Luft, Acta endocr., Copenh.78, 510 (1975).
S. Efendic andR. Luft, Acta endocr., Copenh.78, 516 (1975).
D. J. Koerker, W. Ruch, E. Chodeckel, J. Malmer, C. J. Goodner, J. Ensinck andC. C. Gale, Science184, 482 (1974).
C. H. Mortimer, W. M. G. Tunbridge, D. Carr, L. Yedmass, T. Lind, D. H. Coy, S. R. Bloom, A. J. Kastin, C. N. Mallinson, G. M. Besser, A. V. Schally andR. Hall, Lancet1, 697 (1974).
S. S. C. Yen, M. T. Siler andG. W. Devane New Engl. J. Med.290, 934 (1974).
H. Sakurai, R. Dobbs andR. H. Unger, J. clin. Invest.54, 1395 (1974).
This study was supported by grants from the Swedish Medical Research Council (Nos. 14X-2887 and 19X-3411), from Magnus Bergvalls Stiftelse and from Greta and Harald Jeanssons Stiftelse. The skillful technical assistance of Miss.A. Nygårds is gratefully acknowledged. The generous supply of somatostatin by Dr.R. Guillemin, The Salk Institute, San Diego, California/USA, is gratefully acknowledged.
Author information
Authors and Affiliations
Rights and permissions
About this article
Cite this article
Hökfelt, T., Johansson, O., Efendic, S. et al. Are there somatostatin-containing nerves in the rat gut? Immunohistochemical evidence for a new type of peripheral nerves. Experientia 31, 852–854 (1975). https://doi.org/10.1007/BF01938502
Published:
Issue Date:
DOI: https://doi.org/10.1007/BF01938502