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Cytotoxicity and carcinogenicity of pterosins and pterosides, 1-indanone derivatives from bracken (Pteridium aquilinum)

  • Specialia Pharmacologica
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Zusammenfassung

Über 30 Chemikalien aus getrockneten jungen Blättern und Wurzelstöcken des japanischen FarnkrautesPteridium aquilinum wurden isoliert und als Sesquiterpen-Derivate mit 1-Indanonkern, Pterosine und deren Glukoside, Pteroside, identifiziert. Eine nur geringe Toxizität für HeLa-Zellen ohne Chromosomenschädigung wurde festgestellt. Langzeitfütterung von Pterosin B und Pterosid B ergab keine Tumorbildung in Wistar-Ratten, obwohl die rohen Blätter und Wurzelstöcke kanzerogen waren.

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Author notes

  1. S. Natori, K. Yoshihira, M. Fukuoka & M. Kuroyanagi

    Present address: National Institute of Hygienic Sciences, Kamiyoga-1-Chome, Setagaya-ku, 158, Tokyo, Japan

Authors and Affiliations

  1. Institute of Medical Science, University of Tokyo, Shirokanedai, Minato-ku, 108, Tokyo, Japan

    M. Saito, M. Umeda, M. Enomoto, Y. Hatanaka, S. Natori, K. Yoshihira, M. Fukuoka & M. Kuroyanagi

  2. National Institute of Hygienic Sciences, Kamiyoga-1-Chome, Setagaya-ku, 158, Tokyo, Japan

    M. Saito, M. Umeda, M. Enomoto & Y. Hatanaka

Authors
  1. M. Saito
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  2. M. Umeda
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  3. M. Enomoto
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  4. Y. Hatanaka
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  5. S. Natori
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  6. K. Yoshihira
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  7. M. Fukuoka
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  8. M. Kuroyanagi
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Additional information

This work was supported partly by Grant-in-Aid from the Ministry of Education and the Ministry of Health and Welfare.

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Saito, M., Umeda, M., Enomoto, M. et al. Cytotoxicity and carcinogenicity of pterosins and pterosides, 1-indanone derivatives from bracken (Pteridium aquilinum). Experientia 31, 829–831 (1975). https://doi.org/10.1007/BF01938490

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  • DOI: https://doi.org/10.1007/BF01938490

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