Summary
Twelve subjects with chronic obstructive lung disease and a partially reversible obstruction received increasing single doses of bopindolol (1, 2, 4, and 8 mg), pindolol (7.5, 15, and 30 mg), and atenolol (50 and 100 mg). Resting heart rate and blood pressure were reduced in a dose-dependent fashion. The actions of the drugs on lung function were assessed by whole body plethysmography. Pindolol did not influence mean airway resistance (R aw). Bopindolol (1, 2 and 4 mg) and atenolol (50 mg) exhibited a neutral effect on meanR aw. Atenolol (100 mg) and to a lesser extent bopindolol (8 mg) induced a long-lasting increase in mean Raw.
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Abbreviations
- Raw :
-
airway resistance
- HR:
-
heart rate
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Dorow, P., Schiess, W. Bopindolol, pindolol, and atenolol in patients with chronic obstructive lung disease. Klin Wochenschr 64, 366–369 (1986). https://doi.org/10.1007/BF01728185
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DOI: https://doi.org/10.1007/BF01728185