Summary
A case of recurrent interstitial pneumonia following re-exposure to chlorambucil therapy for chronic lymphocytic leukemia is presented. Chlorambucil is a rare cause of pulmonary disease. The onset of symptoms may occur after only some weeks or after up to several years with no dose-response relationship. Therapy involves the discontinuation of the offending drug and the administration of steroids. The prognosis is poor, with a mortality greater than 50%.
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Mohr, M., Kingreen, D., Rühl, H. et al. Interstitial lung disease — an underdiagnosed side effect of chlorambucil?. Ann Hematol 67, 305–307 (1993). https://doi.org/10.1007/BF01696352
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DOI: https://doi.org/10.1007/BF01696352