Abstract
The action of antitumor sera (ATS) on the adhesive properties of L cells and of Ehrlich's ascites carcinoma cells was studied. The ability of the tumor cells to adhere to plastic and glass and to form rosettes with sheep's red blood cells was reduced after treatment with immune serum and, when injected into mice, fewer of these cells were held up in the lungs, spleen, and liver. The results show that antibodies may play an essential role in the metastasization of tumor cells.
Similar content being viewed by others
Literature Cited
Yu. M. Vasil'ev and A. G. Malenkov, The Cell Surface and Reactions of Cells [in Russian], Leningrad (1968).
I. M. Dozmorov and T. B. Rudneva, in: General Problems in Pathology [in Russian], Vol. 5, Moscow (1977), p. 75.
D. R. Kaulen and T. A. Golovanova, Probl. Gematol., No. 6, 26 (1972).
D. R. Kaulen, V. V. Khorobrykh, and T. A. Golovanova, Byull. Éksp. Biol. Med., No. 7, 77 (1973).
K. A. Lebedev, R. V. Petrov, Yu. M. Lopukhin et al., Zh. Mikrobiol., No. 2, 130 (1977).
W. J. Martin, J. Immunol.,103, 979 (1969).
W. T. Shearer, G. W. Philpott, and C. W. Parker, Cell Immunol.,17, 447 (1975).
Rights and permissions
About this article
Cite this article
Lebedev, K.A., Kaulen, D.R., Khorobrykh, V.V. et al. Migrating ability of tumor cells treated with immune sera. Bull Exp Biol Med 84, 1753–1755 (1977). https://doi.org/10.1007/BF00804827
Received:
Issue Date:
DOI: https://doi.org/10.1007/BF00804827