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Lymphomatoid granulomatosis involving the central nervous system: Complication of a renal transplant with terminal monoclonal B-cell proliferation

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Summary

A 33-year-old man, an immunosuppressed renal allograft recipient, developed fever of unknown etiology, multiple pulmonary densities, space-occupying lesions in the liver, confusion, disorientation, and seizures with cerebral infarcts. At autopsy, changes classical of active lymphomatoid granulomatosis (LYG) were found in the brain but those studied in the lungs and liver were in the healing phase.

In addition, one cerebral focus in the right temporooccipital lobe showed a lymphomatous transformation. Immunofluorescence studies done on this focus showed monoclonal IgG-λ cytoplasmic staining in the perivascular infiltrate. Immunoperoxidase studies confirmed the monoclonal nature of this focus but showed a polyclonal pattern in the other foci. This finding is discussed along with the relationship between LYG and lymphoma.

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Author notes

  1. J. Michaud

    Present address: Dept. of Pathology, Faculty of Medicine, University of Montreal, Station “A”, P.O. Box 6128, H3C 3J7, Montreal, Que., Canada

Authors and Affiliations

  1. Dept. of Pathology and Neuropathology Service, University Hospital and University of Western Ontario, London, Ontario, Canada

    J. Michaud, D. Banerjee & J. C. E. Kaufmann

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  2. D. Banerjee
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  3. J. C. E. Kaufmann
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Michaud, J., Banerjee, D. & Kaufmann, J.C.E. Lymphomatoid granulomatosis involving the central nervous system: Complication of a renal transplant with terminal monoclonal B-cell proliferation. Acta Neuropathol 61, 141–147 (1983). https://doi.org/10.1007/BF00697394

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  • DOI: https://doi.org/10.1007/BF00697394

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