Summary
This study was designed to investigate the effects of griseofulvin, 5-fluorocytosine (5-FC), and amphotericin B on pancreatic and gastric secretion after the administration of a single large dose, or repeated small doses for 3 weeks, in male albino rats.
The exocrine fuctions of the main digestive glands were only slightly affected by griseofulvin and were not affected by 5-FC. In contrast, a single large dose of amphotericin B caused a marked inhibition of exocrine functions of the main digestive glands. The rats treated with 5-FC lost body weight markedly during 2 weeks of administration.
Zusammenfassung
Diese Studie diente der Überprüfung des Einflusses von Griseofulvin, 5-fluorocytosine (5-FC) und Amphotericin B auf die Pankreas- und Magensekretion nach Verabreichung einer einmaligen hohen Dosis oder wiederholten kleineren Dosen für 3 Wochen bei 224 männlichen Albino-Ratten. Die exocrinen Funktionen der Hauptverdauungsdrüsen waren von Griseofulvin nur leicht und von 5-FC gar nicht beeinträchtigt. Im Gegensatz dazu verursachte eine einmalige hohe Dosis von Amphotericin B eine deutliche Inhibition der exocrinen Funktion der Hauptverdauungsdrüsen. Die Ratten, die mit 5-FC behandelt wurden, verminderten deutlich ihr Gewicht nach wiederholter Verabreichung in 2 Wochen.
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Park, YK., Lee, S., Kim, W.J. et al. The effect of antifungal agents on pancreatic and gastric secretion in rats. Arch Dermatol Res 266, 103–108 (1979). https://doi.org/10.1007/BF00694617
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DOI: https://doi.org/10.1007/BF00694617