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Acrylamide-induced peripheral neuropathy in normal and neurofilament-deficient Japanese quails

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Abstract

Morphological effects of acrylamide (AC) on the peripheral nerves in normal and neurofilament (NF)-deficient (Quv) Japanese quails were investigated. AC (100 mg/kg) was injected intraperitoneally every other day. After the birds manifested neurological signs, they were necropsied (after 10 ∼ 21 AC injections) and the sciatic and tibial nerves were examined. In both normal and Quv qualis, AC produced axonopathy with a distal-proximal progression. In AC-intoxicated normal quails, the nerve fiber pathology was characterized by typical Wallerian-like degeneration, consisting of axonal degeneration, myelin breakdown, macrophage migration, Schwann cell proliferation and regeneration of nerve fibers. Ultrastructurally, AC-induced NF accumulation was detected in the axon of myelinated nerve fibers. In AC-intoxicated Quv qualis, axonal degeneration with accumulation of membranous organelles occurred; however, sequential events of Wallerian-like degeneration were not as prominent as in AC-intoxicated normal qualis. These results demonstrated that NF-deficient Quv quails are sensitive to neurotoxic effects of AC. On the other hand, the different pathology of AC-intoxicated normal and Quv qualis indicates the presence or absence of NFs influences the appearance and extent of AC axonopathy.

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Authors and Affiliations

  1. Toxicology Research Laboratories, Japan Tobacco Inc., Hatano, 257, Kanagawa, Japan

    A. Takahashi

  2. Nippon Institute for Biological Science, Kobuchizawa, Kitakomagun, 409-16, Yamanashi, Japan

    M. Mizutani

  3. Department of Comparative Pathology, Faculty of Veterinary Medicine, Hokkaido University, 060, Sapporo, Japan

    C. Itakura

Authors
  1. A. Takahashi
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  2. M. Mizutani
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  3. C. Itakura
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Takahashi, A., Mizutani, M. & Itakura, C. Acrylamide-induced peripheral neuropathy in normal and neurofilament-deficient Japanese quails. Acta Neuropathol 89, 17–22 (1995). https://doi.org/10.1007/BF00294254

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  • DOI: https://doi.org/10.1007/BF00294254

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