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Studies of fatty acid metabolism with positron emission tomography in patients with cardiomyopathy

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Abstract

Positron emission tomography (PET) permits in vivo as well as noninvasive study of fatty acid metabolism. Parameters of 11C-palmitate kinetics relate to the oxidation of fatty acids, and palmitic acid uptake is impaired in patients with coronary disease and cardiomyopathy. Normal myocardium shows homogenous fatty acid·metabolism and can resort to alternate substrates. Diseased myocardium exhibits regional heterogeneity in fatty acid uptake and utilization. In patients with cardiomyopathy, distinct patterns of fatty acid metabolism can be observed following changes of substrate availability by application of an oral glucose load. This intervention also enhances the heterogeneity of 11C-palmitic acid (CPA) uptake and clearance. Thus, PET studies with CPA permit the noninvasive demonstration of effects on substrate availability and may help to characterize patients with ventricular dysfunction on the biochemical level.

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Author notes

  1. E. Henze

    Present address: Division of Radiology III, University of Ulm, School of Medicine, D-7900, Ulm, Federal Republic of Germany

Authors and Affiliations

  1. Division of Nuclear Medicine and Biophysics, Department of Radiological Sciences, UCLA School of Medicine, University of California, 90024, Los Angeles, CA, USA

    H. Sochor, H. R. Schelbert, M. Schwaiger, E. Henze & M. E. Phelps

  2. Laboratory of Nuclear Medicine, Laboratory of Biomedical and Environmental Sciences, University of California, 900 Veteran Avenue, 90024, Los Angeles, CA, USA

    H. Sochor, H. R. Schelbert, M. Schwaiger, E. Henze & M. E. Phelps

Authors
  1. H. Sochor
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  2. H. R. Schelbert
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  3. M. Schwaiger
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  4. E. Henze
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  5. M. E. Phelps
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Additional information

This work was supported in part by the Director of the Office of Energy Research, Office of Health and Environmental Research, by NIH Grants no. HL33177 and by an Investigatorship Group Award by the Greater Los Angeles Affiliate of the American Heart Association, the Laubish Foundation, and the Max Kade Foundation

Operated for the U.S. Department of Energy by the University of California under Contract no. DE-ACO3-76-SF00012

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Sochor, H., Schelbert, H.R., Schwaiger, M. et al. Studies of fatty acid metabolism with positron emission tomography in patients with cardiomyopathy. Eur J Nucl Med 12 (Suppl 1), S66–S69 (1986). https://doi.org/10.1007/BF00258110

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