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Effect of amino acids on rapamycin biosynthesis by Streptomyces hygroscopicus

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Abstract

In a chemically defined medium containing aspartate, arginine and histidine to support good growth, addition of L-lysine stimulated rapamyycin production by 150%. This was probably due to its conversion to pipecolic acid, a rapamycin precursor. Phenylalanine and methionine interfered in rapamycin production by unknown mechanisms.

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  1. Y. R. Cheng

    Present address: Fujian Institute of Microbiology, Fuzhou, People's Republic of China

Authors and Affiliations

  1. Fermentation Microbiology Laboratory, Massachusetts Institute of Technology, 02139, Cambridge, MA, USA

    Y. R. Cheng, A. Fang & A. L. Demain

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  1. Y. R. Cheng
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  2. A. Fang
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  3. A. L. Demain
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Cheng, Y.R., Fang, A. & Demain, A.L. Effect of amino acids on rapamycin biosynthesis by Streptomyces hygroscopicus . Appl Microbiol Biotechnol 43, 1096–1098 (1995). https://doi.org/10.1007/BF00166931

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  • DOI: https://doi.org/10.1007/BF00166931

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