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Microwave-assisted facile synthesis of N, P co-doped fluorescent carbon dot probe for the determination of nifedipine

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Abstract

A simple and fast microwave synthesis method was applied for the preparation of several carbon dots (CDs) from various combinations of urea, phosphoric acid, and B-alanine as nitrogen, phosphorus, and carbon precursors. The maximum quantum yield (44%) was obtained for nitrogen and phosphorus co-doped carbon dots (N, P-CDs) prepared from urea, B-alanine, and phosphoric acid. Furthermore, N, P-CDs were exploited to synthesize a simple and sensitive fluorometric probe to determine nifedipine (NFD). We determined that the analytical response of the designed sensor could be affected by the kind of dopant and synthesis precursors. It is worth mentioning that the fluorescence intensity of N, P-CDs was weakened by NFD, and no fluorescence quenching was observed for other prepared CDs. The NFD-developed sensor demonstrated a linear response range of 3.3 × 10–8–3.2 × 10–5 mol/L, with the detection limit of 1.0 × 10–8 mol/L. The sensor was successfully applied to measure NFD in human biological fluids.

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References

  1. N. Özaltin, C. Yardimci, I. Süslü, J. Pharm. Biomed. Anal. 30, 573–582 (2002)

    Article  PubMed  Google Scholar 

  2. M. Baghayeri, M. Namadchian, H. Karimi-Maleh, H. Beitollahi, J. Electroanal. Chem. 697, 53–59 (2013)

    Article  CAS  Google Scholar 

  3. H.-J. Wang, C.-K. Lu, W.-C. Chen, A.-C. Chen, Y.-F. Ueng, J. Food Drug Anal. 27, 284–294 (2019)

    Article  CAS  PubMed  Google Scholar 

  4. A.G. Ellrodt, M.J. Ault, Am. J. Emerg. Med. 3, 16–24 (1985)

    Article  CAS  PubMed  Google Scholar 

  5. S. Laurent, Pharmacol. Res. 124, 116–125 (2017)

    Article  CAS  PubMed  Google Scholar 

  6. M. Gil-Agustí, S. Carda-Broch, L. Monferrer-Pons, J. Esteve-Romero, Biomed. Chromatogr. 20, 154–160 (2006)

    Article  PubMed  Google Scholar 

  7. M. Vertzoni, C. Reppas, H. Archontaki, Anal. Chim. Acta 573, 298–304 (2006)

    Article  PubMed  Google Scholar 

  8. S. Ahmed, A. Alqurshi, A.-M.I. Mohamed, Talanta 184, 296–306 (2018)

    Article  CAS  PubMed  Google Scholar 

  9. M. Khairy, A.A. Khorshed, F.A. Rashwan, G.A. Salah, H.M. Abdel-Wadood, C.E. Banks, Sens. Actuators B Chem. 252, 1045–1054 (2017)

    Article  CAS  Google Scholar 

  10. J. Tian, M. Huang, Y. Yang, D. Wang, J. Lu, Biosens. Bioelectron. 135, 160–165 (2019)

    Article  CAS  PubMed  Google Scholar 

  11. M. Hamd, A. Abdellatif, S. Derayea, O. Abdelmageed, H. Askal, Ind Chem 1, 2 (2015)

    Google Scholar 

  12. P. Tulasamma, P. Venkateswarlu, Arab. J. Chem. 9, S1603–S1609 (2016)

    Article  CAS  Google Scholar 

  13. A. Iqbal, Y. Tian, X. Wang, D. Gong, Y. Guo, K. Iqbal, Z. Wang, W. Liu, W. Qin, Sens. Actuators B Chem. 237, 408–415 (2016)

    Article  CAS  Google Scholar 

  14. R. Jalili, M. Amjadi, RSC Adv. 5, 74084–74090 (2015)

    Article  CAS  Google Scholar 

  15. H. Eskalen, S. Uruş, Ş Özğan, B. Tahta, A.B. Sünbül, Quantum Dots 96, 81–94 (2021)

    Google Scholar 

  16. Y. Chen, X. Shan, D. Jiang, X. Li, Anal. Sci. 37, 20P433 (2021)

    Google Scholar 

  17. S. Narimani, N. Samadi, Microchem. J. 168, 106372 (2021)

    Article  CAS  Google Scholar 

  18. S. Lei, N. Chang, J. Zhang, H. Wang, Anal. Sci. 37, 20P294 (2020)

    Google Scholar 

  19. P. Zuo, X. Lu, Z. Sun, Y. Guo, H. He, Microchim. Acta 183, 519–542 (2016)

    Article  CAS  Google Scholar 

  20. S. Miao, K. Liang, J. Zhu, B. Yang, D. Zhao, B. Kong, Nano Today 33, 100879 (2020)

    Article  CAS  Google Scholar 

  21. C.-L. Shen, Q. Lou, K.-K. Liu, L. Dong, C.-X. Shan, Nano Today 35, 100954 (2020)

    Article  CAS  Google Scholar 

  22. C.L. Shen, Q. Lou, C.F. Lv, J.H. Zang, S.N. Qu, L. Dong, C.X. Shan, Adv. Sci. 6, 1802331 (2019)

    Article  Google Scholar 

  23. C.L. Shen, Q. Lou, J.H. Zang, K.K. Liu, S.N. Qu, L. Dong, C.X. Shan, Adv. Sci. 7, 1903525 (2020)

    Article  CAS  Google Scholar 

  24. K.M. Omer, A.Q. Hassan, Microchim. Acta 184, 2063–2071 (2017)

    Article  CAS  Google Scholar 

  25. M. Zaib, A. Akhtar, F. Maqsood, T. Shahzadi, Arab. J. Sci. Eng. 46, 437–446 (2021)

    Article  CAS  Google Scholar 

  26. Z. Ma, H. Ming, H. Huang, Y. Liu, Z. Kang, New J. Chem. 36, 861–864 (2012)

    Article  CAS  Google Scholar 

  27. H. Eskalen, S. Uruş, S. Cömertpay, A.H. Kurt, Ş Özgan, Ind. Crops Prod. 147, 112209 (2020)

    Article  CAS  Google Scholar 

  28. S. Xu, S. Ye, Y. Xu, F. Liu, Y. Zhou, Q. Yang, H. Peng, H. **ong, Z. Zhang, Anal. Sci. 36, 19P350 (2019)

    Google Scholar 

  29. J.Y. Wei, Q. Lou, J.H. Zang, Z.Y. Liu, Y.L. Ye, C.L. Shen, W.B. Zhao, L. Dong, C.X. Shan, Adv. Optic. Mater. 8, 1901938 (2020)

    Article  CAS  Google Scholar 

  30. D. Pan, J. Zhang, Z. Li, C. Wu, X. Yan, M. Wu, Chem. Commun. 46, 3681–3683 (2010)

    Article  CAS  Google Scholar 

  31. G.E. LeCroy, S.K. Sonkar, F. Yang, L.M. Veca, P. Wang, K.N. Tackett, J.-J. Yu, E. Vasile, H. Qian, Y. Liu, ACS Nano 8, 4522–4529 (2014)

    Article  CAS  PubMed  Google Scholar 

  32. J.P. Paraknowitsch, A. Thomas, Energy Environ. Sci. 6, 2839–2855 (2013)

    Article  CAS  Google Scholar 

  33. M.K. Barman, B. Jana, S. Bhattacharyya, A. Patra, J. Phys. Chem. C 118, 20034–20041 (2014)

    Article  CAS  Google Scholar 

  34. L. Ansari, S. Hallaj, T. Hallaj, M. Amjadi, Coll. Surf. B 203, 111743 (2021)

    Article  CAS  Google Scholar 

  35. A.B. Bourlinos, G. Trivizas, M.A. Karakassides, M. Baikousi, A. Kouloumpis, D. Gournis, A. Bakandritsos, K. Hola, O. Kozak, R. Zboril, Carbon 83, 173–179 (2015)

    Article  CAS  Google Scholar 

  36. S. Chandra, A.R. Chowdhuri, D. Laha, S.K. Sahu, Luminescence 33, 336–344 (2018)

    Article  CAS  PubMed  Google Scholar 

  37. D. Gu, P. Zhang, L. Zhang, H. Liu, Z. Pu, S. Shang, Opt. Mater. 83, 272–278 (2018)

    Article  CAS  Google Scholar 

  38. K.M. Omer, N.N. Mohammad, S.O. Baban, Catal. Lett. 148, 2746–2755 (2018)

    Article  CAS  Google Scholar 

  39. R. Shokri, M. Amjadi, Spectrochim Acta Part A 246, 118951 (2021)

    Article  CAS  Google Scholar 

  40. E.F. Simões, J.M. Leitão, J.C.E. da Silva, Anal. Chim. Acta 960, 117–122 (2017)

    Article  Google Scholar 

  41. S.Y. Park, H.U. Lee, E.S. Park, S.C. Lee, J.-W. Lee, S.W. Jeong, C.H. Kim, Y.-C. Lee, Y.S. Huh, J. Lee, ACS Appl. Mater. Interf. 6, 3365–3370 (2014)

    Article  CAS  Google Scholar 

  42. J. Jiang, Y. He, S. Li, H. Cui, Chem. Commun. 48, 9634–9636 (2012)

    Article  CAS  Google Scholar 

  43. H. Miao, L. Wang, Y. Zhuo, Z. Zhou, X. Yang, Biosens. Bioelectron. 86, 83–89 (2016)

    Article  CAS  Google Scholar 

  44. J.N. Hart, P.W. May, N.L. Allan, K.R. Hallam, F. Claeyssens, G.M. Fuge, M. Ruda, P.J. Heard, J. Solid State Chem. 198, 466–474 (2013)

    Article  CAS  Google Scholar 

  45. K.M. Omer, D.I. Tofiq, A.Q. Hassan, Microchim. Acta 185, 1–8 (2018)

    Article  CAS  Google Scholar 

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Funding

This research did not receive any specific grant from funding agencies in the public, commercial, or profit sectors.

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Authors and Affiliations

  1. Department of Analytical Chemistry, Faculty of Chemistry, Urmia University, Urmia, Iran

    Saeedeh Narimani & Naser Samadi

  2. Cellular and Molecular Research Center, Cellular and Molecular Medicine Institute, Urmia University of Medical Sciences, 5714783734, Urmia, Iran

    Tooba Hallaj

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  1. Saeedeh Narimani
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  2. Naser Samadi
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  3. Tooba Hallaj
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Correspondence to Saeedeh Narimani.

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Advanced Publication Released Online by J-STAGE November 26, 2021.

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Narimani, S., Samadi, N. & Hallaj, T. Microwave-assisted facile synthesis of N, P co-doped fluorescent carbon dot probe for the determination of nifedipine. ANAL. SCI. 38, 393–399 (2022). https://doi.org/10.2116/analsci.21P287

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  • DOI: https://doi.org/10.2116/analsci.21P287

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