Abstract
A method involving cloud point-salting out extraction (CPSOE) coupled with UHPLC-MS/MS was developed for the determination of eleven sulfonamides in milk. In this study, the type and concentration of the surfactant, de-emulsification condition, pH value, volume of n-butanol, equilibration temperature and time were optimized. For this developed method, the linear range of SAs was from 0.05 to 50 µg L–1, and the correlation coefficients were higher than 0.997. The average recoveries for SAs were from 61.32 to 91.67%, and the LOQs were less than 0.06 µg kg–1.
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This study was supported by The National Key Research and Development Program of China (grant number 2017YFC1601600).
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Li, Z., Zhang, J., Yang, Y. et al. Determination of Sulfonamides in Milk by Cloud Point-Salting Out Extraction and Ultra-High-Performance Liquid Chromatography Tandem Mass Spectrometry. ANAL. SCI. 36, 1555–1559 (2020). https://doi.org/10.2116/analsci.20N013
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DOI: https://doi.org/10.2116/analsci.20N013