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Innate lymphoid cell subsets and their cytokines in autoimmune diseases

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European Cytokine Network

Abstract

Both the innate and adaptive arms of the immune system are involved in the development of autoimmune diseases. The main mechanism of disease is due to adaptive immune cells that are active against self-antigens. These cells can cause major damage to body tissues. Innate lymphoid cells (ILCs) are an important type of innate immune cell, whose role has been highlighted in recent years. ILCs are responsible for some of the inflammation in the pathogenesis of autoimmune diseases. In this review, we discuss the role of ILCs in the immune response, as well as their involvement in various autoimmune diseases.

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Authors and Affiliations

  1. Department of Hematology, School of Allied Medical Sciences, Tehran University of Medical Sciences (TUMS), Tehran, Iran

    Asma Maleki, Jamal Motallebzadeh Khanmiri & Mohammad Khani Eshrat Abadi

  2. School of Medicine, Tehran University of Medical Sciences, Tehran, Iran

    Faezeh Soveyzi

  3. Research Center for Immunodeficiencies, Pediatrics Center of Excellence, Children’s Medical Center, Tehran University of Medical Science, 62 Qarib St, Keshavarz Blvd, Tehran, 14194, Iran

    Bobak Moazzami & Nima Rezaei

  4. Network of Immunity in Infection, Malignancy and Autoimmunity (NIIMA), Universal Scientific Education and Research Network (USERN), Tehran, Iran

    Bobak Moazzami & Nima Rezaei

  5. Laser Research Centre, Faculty of Health Science, University of Johannesburg, Doornfontein, Johannesburg, 2028, South Africa

    Michael R. Hamblin

  6. Network of Immunity in Infection, Malignancy and Autoimmunity (NIIMA), Universal Scientific Education and Research Network (USERN), Johannesburg, 2028, South Africa

    Michael R. Hamblin

  7. Department of Immunology, School of Medicine, Tehran University of Medical Sciences, Tehran, Iran

    Nima Rezaei

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  1. Asma Maleki
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  2. Jamal Motallebzadeh Khanmiri
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  3. Mohammad Khani Eshrat Abadi
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  4. Faezeh Soveyzi
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  5. Bobak Moazzami
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  6. Michael R. Hamblin
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  7. Nima Rezaei
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Correspondence to Nima Rezaei.

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Maleki, A., Khanmiri, J.M., Eshrat Abadi, M.K. et al. Innate lymphoid cell subsets and their cytokines in autoimmune diseases. Eur Cytokine Netw 31, 118–128 (2020). https://doi.org/10.1684/ecn.2020.0460

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