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Formulation and Development of Flurbiprofen Colon-Specific Eudragit Coated Matrix Tablets: Use of a Novel Crude Banana Peel Powder as a Time-Dependent Polymer

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Abstract

The rationale for the current investigation is to study the crude banana peel (CBP) powder efficiency as a novel natural time-dependent polymer along with a pH-sensitive polymer to develop flurbiprofen colon-specific tablets. The direct compression method is utilized to prepare the flurbiprofen-CBP matrix tablets using 9 mm punches on the rotary tableting machine and subsequently coated with Eudragit® S 100 by a dip coating method. The tablets were evaluated for various tableting properties and in vitro drug release studies. From the results of dissolution studies, the F6 formulation showed negligible drug release (5.76% in 5 h) in the upper gastrointestinal tract and progressive release in the colon (99.08% in 24 h). Mean dissolution time, T10%, and T80% were found to be 13.33 h, 5.8 h, and 20.7 h, respectively, which explains the efficiency of the present combination of polymers for colon-specific drug release. From the dissolution studies results of stability studies, the similarity index was calculated and found to be 74.75. In conclusion, utilizing CBP as a natural, time-dependent polymer in conjunction with Eudragit® S 100 to develop the flurbiprofen tablets seems like a promising approach for delivering drugs specifically to the colon.

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Data Availability

The datasets generated during and/or analyzed during the current study are available from the corresponding author upon reasonable request.

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Acknowledgements

The authors acknowledge GITAM School of Pharmacy, Hyderabad, Telangana, India, and School of Pharmaceutical Sciences, Lovely Professional University, Jalandhar, Punjab, India, for providing chemicals and facilities for the successful completion of work.

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Authors and Affiliations

  1. Department of Pharmaceutics and Drug Delivery, School of Pharmacy, The University of Mississippi, University, Mississippi, 38677, USA

    Sateesh Kumar Vemula & Michael Repka

  2. Department of Pharmaceutics, School of Pharmaceutical Sciences, Lovely Professional University, Phagwara, Punjab, India

    Sateesh Kumar Vemula

  3. Department of Pharmaceutics, GITAM School of Pharmacy, GITAM Deemed to Be University, Rudraram, Patancheru, Sangareddy, Hyderabad, Telangana, India

    Bhaskar Daravath

  4. Sri Shivani College of Pharmacy, Mulugu Road, Warangal, Telangana, India

    Sridhar Babu Gummadi

  5. Pii Center for Pharmaceutical Technology, The University of Mississippi, University, Mississippi, 38677, USA

    Michael Repka

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  1. Sateesh Kumar Vemula
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Contributions

Sateesh Kumar Vemula and Bhaskar Daravath: formulation design and experimental work. Sridhar Babu Gummadi: concept and preparation of CBP powder. Sateesh Kumar Vemula and Bhaskar Daravath: writing—original draft. Michael Repka: review and editing.

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Correspondence to Sateesh Kumar Vemula or Michael Repka.

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Vemula, S.K., Daravath, B., Gummadi, S.B. et al. Formulation and Development of Flurbiprofen Colon-Specific Eudragit Coated Matrix Tablets: Use of a Novel Crude Banana Peel Powder as a Time-Dependent Polymer. AAPS PharmSciTech 24, 189 (2023). https://doi.org/10.1208/s12249-023-02646-0

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