SpringerLink
Log in

The Effect of Atosiban on Patients With Difficult Embryo Transfers Undergoing In Vitro Fertilization–Embryo Transfer

  • Published:
Reproductive Sciences Aims and scope Submit manuscript

Abstract

The purpose of this study was to evaluate the effect of atosiban on the outcomes of infertile women undergoing in vitro fertilization (IVF) with difficult embryo transfers (ETs). This randomized double-blind study enrolled 204 infertile women with difficult ETs during IVF treatment between June 2014 and June 2018. According to a computer-generated randomization list, participants were randomized into placebo (n = 102) and atosiban (n = 102) groups. In atosiban group, atosiban with a total dose of 37.5 mg was administered. All of the patients underwent IVF-ET using cryopreserved embryos. The clinical pregnancy rate per cycle and implantation rate per transfer (45.1% and 26.5%) in atosiban group were significantly higher than those of placebo group (15.6% and 9.7%, respectively; P <.05). This study showed that administration of atosiban during ET was extraordinarily effective for patients with difficult transfers.

This is a preview of subscription content, log in via an institution to check access.

Access this article

Log in via an institution

Subscribe and save

Springer+ Basic
EUR 32.99 /Month
  • Get 10 units per month
  • Download Article/Chapter or Ebook
  • 1 Unit = 1 Article or 1 Chapter
  • Cancel anytime
Subscribe now

Buy Now

Price includes VAT (France)

Instant access to the full article PDF.

Institutional subscriptions

Similar content being viewed by others

References

  1. Nielsen IK, Lindhard A, Loft A, Ziebe S, Andersen AN. A Wallace malleable stylet for difficult embryo transfer in an in vitro fertilization program: a case-control study. Acta Obstet Gynecol Scand. 2002;81(2):133–137.

    Article  Google Scholar 

  2. Spandorfer SD, Goldstein J, Navarro J, Veeck L, Davis OK, Rosenwaks Z. Difficult embryo transfer has a negative impact on the outcome of in vitro fertilization. Fertil Steril. 2003;79(3):654–655.

    Article  Google Scholar 

  3. Phillips JA, Martins WP, Nastri CO, Raine-Fenning NJ. Difficult embryo transfers of blood on catheter and assistant reproductive outcomes: a systematic review and meta-analysis. Eur J Obstet Gynecol Reprod Biol. 2013;168(2):121–128.

    Article  Google Scholar 

  4. Romero R, Sibai BM, Sanchez-Ramos L, et al. An oxytocin receptor antagonist (atosiban) in the treatment of preterm labor: a randomized, double-blind, placebo-controlled trial with tocolytic rescue. Am J Obstet Gynecol. 2000;182(5):1173–1183.

    Article  CAS  Google Scholar 

  5. Pierzynski P, Gajda B, Smorag Z, Rasmussen AD, Kuczynski W. Effect of atosiban on rabbit embryo development and human sperm motility. Fertil Steril. 2007;87(5):1147–1152.

    Article  CAS  Google Scholar 

  6. Akerlund M. Involvement of oxytocin and vasopressin in the pathophysiology of preterm labor and primary dysmenorrhea. Prog Brain Res. 2002;139:359–365.

    Article  CAS  Google Scholar 

  7. Pierzynski P, Reinheimer TM, Kuczynski W. Oxytocin antagonists may improve infertility treatment. Fertil Steril. 2007;88(1): 213 e19–213 e22.

    Article  Google Scholar 

  8. Spandorfer SD, Avrech OM, Colombero LT, Palermo GD, Rosenwaks Z. Effect of parental age on fertilization and pregnancy characteristics in couples treated by intracytoplasmic sperm injection. Hum Reprod. 1998;13(2):334–338.

    Article  CAS  Google Scholar 

  9. Goodwin TM, Millar L, North L, Abrams LS, Weglein RC, Holland ML. The pharmacokinetics of the oxytocin antagonist atosiban in pregnant women with preterm uterine contractions. Am J Obstet Gynecol. 1995;173(3 pt 1):913–917.

    Article  CAS  Google Scholar 

  10. Moraloglu O, Tonguc E, Var T, Zeyrek T, Batioglu S. Treatment with oxytocin antagonists before embryo transfer may increase implantation rates after IVF. ReprodBioMed Online. 2010;21(3):338–343.

    Article  CAS  Google Scholar 

  11. Lan VT, Khang VN, Nhu GH, Tuong HM. Atosiban improves implantation and pregnancy rates in patients with repeated implantation failure. Reprod BioMed Online. 2012;25(3):254–260.

    Article  CAS  Google Scholar 

  12. Listijono DR, Boylan T, Cooke S, Kilani S, Chapman MG. An analysis of the impact of embryo transfer difficulty on live birth rates, using a standardised grading system. Hum Fertil (Camb). 2013;16(3):211–214.

    Article  Google Scholar 

  13. Lesny P, Killick SR, Robinson J, Raven G, Maguiness SD. Junctional zone contractions and embryo transfer: is it safe to use a tenaculum? Hum Reprod. 1999;14(9):2367–2370.

    Article  CAS  Google Scholar 

  14. Knutzen V, Stratton CJ, Sher G, McNamee PI, Huang TT, Soto-Albors C. Mock embryo transfer in early luteal phase, the cycle before in vitro fertilization and embryo transfer: a descriptive study. Fertil Steril. 1992;57(1):156–162.

    Article  CAS  Google Scholar 

  15. Fanchin R, Righini C, Olivennes F, Taylor S, de Ziegler D, Frydman R. Uterine contractions at the time of embryo transfer alter pregnancy rates after in-vitro fertilization. Hum Reprod. 1998;13(7):1968–1974.

    Article  CAS  Google Scholar 

  16. Zhu L, Che HS, **ao L, Li YP. Uterine peristalsis before embryo transfer affects the chance of clinical pregnancy in fresh and frozen-thawed embryo transfer cycles. Hum Reprod. 2014;29(6):1238–1243.

    Article  CAS  Google Scholar 

  17. Pierzynski P. Oxytocin and vasopressin V(1A) receptors as new therapeutic targets in assisted reproduction. Reprod Biomed Online. 2011;22(1):9–16.

    Article  CAS  Google Scholar 

  18. Liang YL, Kuo TC, Hung KH, Chen TH, Wu MH. Oxytocin antagonist for repeated implantation failure and delay ofdelivery. Taiwan J Obstet Gynecol. 2009;48(3):314–316.

    Article  Google Scholar 

  19. Chou PY, Wu MH, Pan HA, Hung KH, Chang FM. Use of an oxytocin antagonist in in vitro fertilization embryo transfer for women with repeated implantation failure: a retrospective study. Taiwan JObstet Gynecol. 2011;50(2):136–140.

    Article  Google Scholar 

  20. Ng EH, Li RH, Chen L, Lan VT, Tuong HM, Quan S. A randomized double blind comparisonofatosibaninpatients undergoing IVF treatment. Hum Reprod. 2014;29(12):2687–2689.

    Article  CAS  Google Scholar 

Download references

Acknowledgments

The authors acknowledge the physicians, nurses, and scientific staff of Department of Reproductive Medicine, Shanxi Provincial People’s Hospital, especially thank Dr Qinqin for the linguistic revision of the manuscript.

Author information

Authors and Affiliations

  1. Department of Gynecology & Obstetrics, Qilu Hospital, Shandong University, **an, 250012, People’s Republic of China

    Caixia Yuan (MD), Shili Su (MM) & Baihua Dong (MD, PhD)

  2. Department of Reproductive Medicine, Shanxi Provincial People’s Hospital, Taiyuan, People’s Republic of China

    Caixia Yuan (MD), Haixia Song (MD) & Lingling Fan (MM)

Authors
  1. Caixia Yuan
    View author publications

    You can also search for this author in PubMed Google Scholar

  2. Haixia Song
    View author publications

    You can also search for this author in PubMed Google Scholar

  3. Lingling Fan
    View author publications

    You can also search for this author in PubMed Google Scholar

  4. Shili Su
    View author publications

    You can also search for this author in PubMed Google Scholar

  5. Baihua Dong
    View author publications

    You can also search for this author in PubMed Google Scholar

Corresponding author

Correspondence to Baihua Dong.

Rights and permissions

Reprints and permissions

About this article

Check for updates. Verify currency and authenticity via CrossMark

Cite this article

Yuan, C., Song, H., Fan, L. et al. The Effect of Atosiban on Patients With Difficult Embryo Transfers Undergoing In Vitro Fertilization–Embryo Transfer. Reprod. Sci. 26, 1613–1617 (2019). https://doi.org/10.1177/1933719119831791

Download citation

  • Published:

  • Issue Date:

  • DOI: https://doi.org/10.1177/1933719119831791

Keywords

Search

Navigation